Genetic initiation of hypertensive and diabetic nephropathy

American Journal of Hypertension
Barry I FreedmanR G Appel

Abstract

The factors initiating the common etiologies of chronic renal failure remain elusive. This article reviews the evidence in support of a generalized genetic susceptibility to human end-stage renal disease, including kidney failure attributed to the systemic diseases of hypertension, diabetes mellitus, and glomerulonephritis. Molecular genetic techniques are powerful tools, assisting in the detection of the initiating factors in many complex diseases. In kidney disease, genetic methodologies complement the available anatomic, epidemiologic, and physiologic analyses. This article provides strategies to allow for the detection of human renal failure susceptibility genes. The identification of human renal failure genes would provide useful markers for disease susceptibility and speed the development of novel therapeutic strategies.

Citations

Oct 25, 2006·Current Cardiology Reports·Yousri M Barri
Mar 28, 2008·Current Hypertension Reports·Yousri M Barri
Sep 3, 2010·Diabetes Technology & Therapeutics·Wan-Ju KungHso-Chi Chaung
Sep 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F C Luft
Jun 10, 2000·Current Opinion in Nephrology and Hypertension·B I Freedman, S G Satko
Apr 10, 2004·Current Opinion in Nephrology and Hypertension·Scott G Satko, Barry I Freedman
Jul 23, 1999·Renal Failure·V M Buckalew, B I Freedman
Jul 2, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barry I FreedmanDonald W Bowden
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Sudha K IyengarJohn R Sedor
Feb 14, 2002·Kidney International·Sudha K IyengarJohn R Sedor
Nov 25, 2003·Kidney International·Robert B Toto
Aug 4, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B I FreedmanS Pegram
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Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B I FreedmanW M McClellan

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