Genetic insights into the neurodevelopmental origins of schizophrenia

Nature Reviews. Neuroscience
Rebecca Birnbaum, Daniel R Weinberger

Abstract

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of neurobiological investigation. Although the underlying causal mechanisms remain unknown, early neurodevelopmental events have been implicated in pathogenesis, initially by epidemiological and circumstantial data but more recently by brain-specific molecular and genetic findings. Notably, genomic research has recently uncovered discrete risk variants and risk loci associated with schizophrenia, with the potential to elucidate disease mechanisms. This Review revisits the neurodevelopmental model of schizophrenia from a current genetics perspective, delineating the complex genetic basis of the disorder and highlighting gene expression and epigenetic analyses of post-mortem cortical tissue that suggest that early brain development mediates genetic risk associated with schizophrenia. Future functional genomics investigations will accordingly need to characterize schizophrenia risk loci in relevant neurodevelopmental models.

References

Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·P SeemanK Wong
Dec 1, 1992·Archives of General Psychiatry·E S Susser, S P Lin
Nov 1, 1991·The American Journal of Psychiatry·K L DavisM Davidson
Jan 2, 1988·British Medical Journal·R M Murray, S W Lewis
Jul 8, 1988·Science·P Rakic
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Aug 1, 1994·Archives of General Psychiatry·T D CannonR A Price
Aug 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B K LipskaD R Weinberger
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·P S Goldman-Rakic
Jan 1, 1997·Journal of Psychopharmacology·A F Arnsten
Aug 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B K Lipska, D R Weinberger
Jul 4, 2001·Nature Reviews. Neuroscience·M H Johnson
Dec 26, 2001·Archives of General Psychiatry·S L BukaR H Yolken
Jun 8, 2002·Annual Review of Neuroscience·David A Lewis, Pat Levitt
Jul 2, 2002·The American Journal of Psychiatry·Mary CannonRobin M Murray
Jul 12, 2002·Journal of Neural Transmission·S Heckers, C Konradi
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Jan 1, 1963·Acta Pharmacologica Et Toxicologica·A CARLSSON, M LINDQVIST
Oct 7, 2003·Annual Review of Neuroscience·Elizabeth A Grove, Tomomi Fukuchi-Shimogori
Oct 24, 2003·Brain Research. Brain Research Reviews·Diego EchevarríaSalvador Martínez
Dec 10, 2003·Archives of General Psychiatry·Patrick F SullivanMichael C Neale
Feb 20, 2004·The International Journal of Neuropsychopharmacology·Anissa Abi-Dargham
Feb 9, 2005·Molecular Psychiatry·J L RapoportM R C Psych
Aug 4, 2005·JAMA : the Journal of the American Medical Association·David St ClairLin He
Nov 30, 2005·Nature Reviews. Molecular Cell Biology·Magdalena Götz, Wieland B Huttner
Jun 15, 2006·Cellular and Molecular Neurobiology·Joseph T Coyle
Jun 17, 2006·Annual Review of Neuroscience·Robert R BussRonald W Oppenheim
Sep 22, 2006·Nature Reviews. Neuroscience·Andreas Meyer-Lindenberg, Daniel R Weinberger
Nov 6, 2007·Biological Psychiatry·Stephen L BukaUNKNOWN Collaborative Study Group on the Perinatal Origins of Severe Psychiatric Disorders
Dec 7, 2007·Archives of General Psychiatry·Timothea ToulopoulouRobin Murray

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Citations

Nov 28, 2018·Nature Reviews. Genetics·María Berdasco, Manel Esteller
Feb 28, 2018·Molecular Psychiatry·Gabriel E HoffmanKristen J Brennand
May 6, 2019·The American Journal of Psychiatry·Leslie G NuciforaFrederick C Nucifora
May 17, 2019·International Journal of Psychiatry in Clinical Practice·Qing-Rong XiaYa-Yun Xu
Aug 3, 2018·Translational Psychiatry·Junfang ChenEmanuel Schwarz
Jun 19, 2019·Human Molecular Genetics·Veronica L HoodAmanda J Law
May 14, 2019·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Kisho Obi-NagataAkiko Hayashi-Takagi
Sep 17, 2019·Psychiatry and Clinical Neurosciences·Milica J NesicNadja P Maric
Oct 28, 2019·EMBO Molecular Medicine·Masayuki IdeTakeo Yoshikawa
Dec 25, 2019·Journal of Neurogenetics·Ari Berkowitz
Feb 15, 2019·Current Opinion in Psychiatry·Christin WeisslederCynthia Shannon Weickert
Nov 14, 2019·British Journal of Pharmacology·Maria A MeierZoltan Gerevich
Feb 29, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan A HollanderChristine Ladd-Acosta
Apr 18, 2020·Molecular Autism·Aaron Gordon, Daniel H Geschwind
Dec 12, 2018·Brain : a Journal of Neurology·Timothea ToulopoulouDaniel R Weinberger
May 28, 2019·Nature Reviews. Neuroscience·Martijn P van den Heuvel, Olaf Sporns
Jul 10, 2019·Scientific Reports·Jorge Lopez-CastromanEnrique Baca-García
Jul 11, 2019·Genome Biology·Isabel MendizabalSoojin V Yi
Dec 17, 2017·The European Journal of Neuroscience·Mohamed A SherifPatrick D Skosnik
Jun 20, 2018·International Immunology·Shogo Tanabe, Toshihide Yamashita
Dec 24, 2018·Frontiers in Behavioral Neuroscience·Anke Hoffmann, Dietmar Spengler
Jan 31, 2019·Translational Psychiatry·Christoph A ZimmermannElisabeth B Binder
Mar 29, 2018·Medicines·Konstantinos AssimakopoulosEvangelia Eirini Tsermpini
May 16, 2019·Pharmacology Research & Perspectives·Maiko TanakaHaruhide Kimura
Oct 5, 2019·International Journal of Molecular Sciences·Anke HoffmannDietmar Spengler
Aug 10, 2019·Frontiers in Genetics·Anke Hoffmann, Dietmar Spengler
May 15, 2020·Molecular Psychiatry·Amanda J PriceDaniel R Weinberger

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