Abstract
To investigate what kind of genetic instability plays important roles in lung carcinogenesis, we analyzed micro- and minisatellite instability, loss of heterozygosity (LOH) and chromosome instability in 55 cases of lung cancer, including, 10 squamous cell, 5 large cell, and 3 small cell carcinomas, and 37 adenocarcinomas. Analysis of minisatellite instability, the mechanism of which is different from microsatellite instability, has not been reported previously. Minisatellite instability was detected in only one case (1/55, 1.8%), and the frequency of microsatellite instability was low, being found only in three cases (3/55, 5.5%). In contrast, LOH, for at least in one locus, was observed in 27 cases (49.1%). In adenocarcinomas, the frequency of LOH was higher in poorly differentiated compared to more differentiated carcinomas. For chromosome instability, a similar correlation between differentiation grade and instability was observed in adenocarcinomas. And instability was more common in large cell and small cell carcinomas than in adenocarcinomas. Our analysis showed that chromosome instability and LOH, rather than mini- and microsatellite instability, play significant roles in the development of lung cancer.
References
Jul 5, 1991·Science·M HollsteinC C Harris
Mar 7, 1985·Nature·A J JeffreysS L Thein
Mar 1, 1995·Nature Genetics·S T BennettF Pociot
May 1, 1994·International Journal of Radiation Biology·S SadamotoO Niwa
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·L MaoD Sidransky
Dec 3, 1993·Cell·R FishelR Kolodner
Dec 17, 1993·Cell·F S LeachM Nyström-Lahti
Aug 19, 1993·The New England Journal of Medicine·T G KrontirisN Risch
May 7, 1993·Science·L A AaltonenS R Hamilton
Apr 25, 1996·Nature·Y E DubrovaA J Jeffreys
May 1, 1997·Molecular and Cellular Biology·E A SiaT D Petes
Apr 1, 1997·Nature Genetics·F MitelmanB Johansson
Jan 1, 1999·Nature·C LengauerB Vogelstein
Feb 2, 1999·Genetics·R J KokoskaT D Petes
Apr 6, 1999·Carcinogenesis·K GotohT Mitsudomi
Mar 14, 2000·European Journal of Human Genetics : EJHG·G StevaninA Brice
Jun 18, 2002·The EMBO Journal·Judith LopesAlain Nicolas
Oct 3, 2002·Cancer Letters·Yuichi IshikawaEiju Tsuchiya
Apr 5, 2003·Genomics·Philippe R J Bois
Nov 19, 2004·Nature·Harith Rajagopalan, Christoph Lengauer
Citations
Jun 3, 2014·PloS One·Chenghua WangChunqing Zhang
Jun 14, 2014·Oncology Reports·Kentaro InamuraYuichi Ishikawa
Oct 11, 2007·BMC Cancer·Anjan MisraSubrata Sinha
Jul 29, 2008·Nucleic Acids Research·Matthias BahrElmar Weinhold
May 6, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yen-Tsung HuangDavid C Christiani
May 30, 2009·Croatian Medical Journal·Zoran BudimlijaMechthild Prinz
Jan 8, 2013·BMC Cancer·Hironori NinomiyaYuichi Ishikawa
Dec 8, 2015·Virchows Archiv : an International Journal of Pathology·Arne WarthMatthias Kloor
Nov 2, 2007·The Journal of Pathology·H-S HsuY-C Wang
Oct 11, 2008·Pathology International·Kazuya ShinmuraHaruhiko Sugimura
Nov 26, 2010·Pathology International·Keiju AokageAtsushi Ochiai
Oct 26, 2005·Oncogene·L HummerichP Angel
Feb 1, 2011·Virchows Archiv : an International Journal of Pathology·Xiao-Jie DingYi Cao
Oct 3, 2019·Scientific Reports·Lingling LiLiuyong Pang
Oct 27, 2007·American Journal of Respiratory and Critical Care Medicine·Mathieu SalaünLuc Thiberville
Feb 18, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan C DudleyJames R Eshleman
Jan 18, 2021·Mutagenesis·V G DruzhininA Fucic
Jul 18, 2009·The Annals of Applied Statistics·Robert B ScharpfIngo Ruczinski
Jul 22, 2011·Chemical Reviews·Sunil K Arya, Shekhar Bhansali
Jul 28, 2009·Journal of Experimental & Clinical Cancer Research : CR·Tadahiko NakamuraHideo Baba
Oct 13, 2021·Environmental and Molecular Mutagenesis·Stephanie BinderRalf Zimmermann
Nov 16, 2021·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Pedro De MarchiRui Manuel Reis