Genetic Instability of a Polydactyl Hypopigmented Cat With Squamous Cell Carcinoma-A Case Report

Frontiers in Veterinary Science
María Evarista Arellano-GarcíaO Torres-Bugarín

Abstract

Polydactyly, hypopigmentation, and squamous cell carcinoma are common in cats. However, a cat exhibiting all of these conditions has not yet been reported. This study presents the case of a 14- year-old male Mexican cat, hypopigmented, with supernumerary fingers, two preaxial and one on each posterior limb, admitted to the clinic with a lesion in the left periocular region. The cat was subjected to a general physical examination, blood, and urine chemistry, as well as a biopsy and genomic instability assessment with an analysis of the red blood cells (RBC) micronucleated erythrocytes (RBC-MNE) in the peripheral blood. The biopsy was positive for squamous cell carcinoma, and the RBC-MNE count (8.6 MNE/1000 erythrocytes) was high compared to that previously described in other domestic cats or wild cats. Thus, the genomic instability of the RBC-MNE could be used as an indicator to identify clinical conditions of felines, particularly those with one of the characteristics exhibited by this Mexican cat. The RBC-MNE test is the most widely used in the world for the evaluation of DNA damage, but to our knowledge, it has not been used to identify vulnerable non-human specimens.

References

Jul 10, 1996·Mutation Research·G ZúñigaJ Sánchez-Corona
Nov 1, 1961·The Anatomical Record·V A CHAPMAN, F N ZEINER
Sep 24, 2004·Physiological Reviews·Andrzej SlominskiJacobo Wortsman
Jan 24, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·H Donmez-AltuntasH Demirtas
Dec 18, 2010·Mutagenesis·Takeshi MoritaMakoto Hayashi
Jan 3, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Alka Bhatia, Yashwant Kumar
Apr 30, 2014·Disease Markers·Olivia Torres-BugarínMaría Luisa Ramos-Ibarra
Jul 16, 2014·AIDS Research and Human Retroviruses·Liviu FellerJohan Lemmer
Jul 16, 2015·Pigment Cell & Melanoma Research·Marco d'IschiaShosuke Ito
Feb 11, 2016·Journal of Feline Medicine and Surgery·Alexia HamelinMarie Abitbol
Oct 14, 2016·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Makoto Hayashi
May 13, 2018·International Journal of Cosmetic Science·C SerreJ-M Botto

❮ Previous
Next ❯

Methods Mentioned

BETA
Fluorescence
biopsy
environmental stress

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

The Journal of Heredity
C H DANFORTH
Journal of Feline Medicine and Surgery
Alexia HamelinMarie Abitbol
Annales de dermatologie et de vénéréologie
M Perier-MuzetS Dalle
© 2022 Meta ULC. All rights reserved