Genetic interactions among scribbler, Atrophin and groucho in Drosophila uncover links in transcriptional repression.

Genetics
Amy Wehn, Gerard Campbell

Abstract

In eukaryotes, the ability of DNA-binding proteins to act as transcriptional repressors often requires that they recruit accessory proteins, known as corepressors, which provide the activity responsible for silencing transcription. Several of these factors have been identified, including the Groucho (Gro) and Atrophin (Atro) proteins in Drosophila. Here we demonstrate strong genetic interactions between gro and Atro and also with mutations in a third gene, scribbler (sbb), which encodes a nuclear protein of unknown function. We show that mutations in Atro and Sbb have similar phenotypes, including upregulation of the same genes in imaginal discs, which suggests that Sbb cooperates with Atro to provide repressive activity. Comparison of gro and Atro/sbb mutant phenotypes suggests that they do not function together, but instead that they may interact with the same transcription factors, including Engrailed and C15, to provide these proteins with maximal repressive activity.

References

Jun 1, 1990·Genes & Development·S Eaton, T B Kornberg
Sep 1, 1997·Molecular and Cellular Biology·B D AronsonJ P Gergen
Jul 31, 1998·Development Genes and Evolution·D KosmanJ Reinitz
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·H Zhang, M Levine
Feb 18, 1999·Molecular and Cellular Biology·G JiménezD Ish-Horowicz
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y RaoS L Zipursky
Jul 16, 2002·Nature Neuroscience·Joshua S KaminkerUtpal Banerjee
Jun 6, 2003·Cellular and Molecular Life Sciences : CMLS·K Gaston, P S Jayaraman
Feb 21, 2004·Current Topics in Developmental Biology·Judith K Davie, Sharon Y R Dent
Jul 15, 2004·PLoS Biology·Daniella Bianchi-FriasSusan M Parkhurst
Nov 13, 2004·Development·Stephanie E Winter, Gerard Campbell

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Citations

Nov 26, 2013·Developmental Biology·William A RogersThomas M Williams
Jul 5, 2011·Developmental Biology·Takeshi YorimitsuHideki Nakagoshi
Oct 26, 2013·Experimental Cell Research·Mattias Mannervik
Apr 11, 2017·PLoS Genetics·Luis Humberto Mojica-VázquezMuriel Boube
Dec 2, 2008·Nuclear Receptor Signaling·Lei Wang, Chih-Cheng Tsai

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