PMID: 6936601Jan 1, 1980

Genetic interactions in the control of mitochondrial functions in Paramecium. I. Interactions between nuclear genes

Molecular & General Genetics : MGG
F Ruiz, J Beisson

Abstract

The genetic and physiological properties of two nuclear mutants of Paramecium tetraurelia affecting mitochondrial properties, and first screened as resistant to tetrazolium (TTC) are described. The mutant TTC64-1R is strongly deficient in cytochrome c and the mutant TTC66pR is partially deficient in cytochrome aa3; both mutants display cyanide insensitive respiration in exponential growth phase. In the double mutant TTC64-1R -- TTC66pR/TTC64-1R -- TTC66pR the deficiency in cytochrome aa3 due to the TTC66pR mutation is suppressed. The mutation TTC64-1R does not suppress cytochrome aa3 deficiencies due to mitochondrial mutations, but does interact with another nuclear mutation, cl1, (compatible only with mitochondria deficient in cytochrome oxidase) in such a way that the double mutant TTC64-1R -- cl1/TTC64-1R -- cl1 displays a normal amount of cytochrome aa3. The possible mechanisms and physiological significance of these suppressive effects are discussed.

References

Jun 24, 1977·Molecular & General Genetics : MGG·H BertrandC A Zagozeski
Jun 1, 1978·Molecular & General Genetics : MGG·F Ruiz, A Adoutte
Oct 25, 1978·Molecular & General Genetics : MGG·H Bertrand, R A Collins
Feb 15, 1973·European Journal of Biochemistry·G von JagowM Klingenberg
Apr 1, 1973·Journal of Bacteriology·D L EdwardsJ Horstmann
May 21, 1974·Molecular & General Genetics : MGG·A SainsardM Balméfrézol
Feb 1, 1969·Genetical Research·J Beisson, M Rossignol

Citations

Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yiorgos ApidianakisLaurence G Rahme
Mar 31, 2004·The Journal of Cell Biology·Enrico S Montana, J Troy Littleton
Dec 27, 1996·The Journal of Biological Chemistry·D ChagnovichS L Cohn
May 2, 2006·Genetics·Tim FergestadBarry Ganetzky
Feb 5, 2008·Genetics·Tim FergestadBarry Ganetzky

Related Concepts

Metazoa
Cytochromes
Antibiotic Resistance, Microbial
Cistron
Mitochondria
Paramecium
Tetrazolium Salts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.