Genetic interactions model among Eotaxin gene polymorphisms in asthma.

Journal of Human Genetics
June-Hyuk LeeHyoung Doo Shin

Abstract

Eotaxin family (Eotaxin 1,2 and 3) recruits and activates CCR3-bearing cells such as eosinophil, mast cells, and Th2 lymphocytes that play a major role in allergic disorders. We examined the polygenetic effects of the Eotaxin gene family in a Korean population. Gene-gene interactions were tested using a multistep approach with multifactor dimensionality reduction (MDR) method between asthmatics and normal controls. The overall best MDR model of the main effect single nucleotide polymorphisms (SNPs) included EOT2 + 1272A > G and EOT3 + 77C > T (model 1) [testing accuracy 0.597, cross-validation consistency (CVC) 10/10, P < 0.001]. The overall best MDR model of the SNPs with no main effects included EOT2 + 304C > A, EOT3 + 716A > G, and EOT3 + 1579G > A (model 2) (testing accuracy 0.616, CVC 10/10, P < 0.001). Model 3 was obtained by including the MDR variables for models 1 and 2. This new composite model predicted asthma with better accuracy than either model 1 or model 2 (testing accuracy 0.643, CVC 10/10, P < 0.001). The detection of statistical interaction models is one evidence of gene-gene interactions among Eotaxin genes, and this interaction is thought to influence the development of asthma. Although the models are limite...Continue Reading

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Citations

Jun 28, 2011·Respiratory Research·Erik MelénKelan G Tantisira
Apr 20, 2011·Periodontology 2000·Jincai ZhangGang Luo
Mar 2, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Won-Ah ChoiSoo-Jong Hong
Apr 8, 2011·Journal of Human Genetics·Ewelina PośpiechWojciech Branicki
Oct 4, 2011·Allergy, Asthma & Immunology Research·Shin-Hwa LeeChoon-Sik Park
Jul 6, 2014·Allergy, Asthma & Immunology Research·June-Hyuk Lee, Choon-Sik Park
Jul 2, 2010·Allergy, Asthma & Immunology Research·You-Young Kim
Oct 5, 2010·Allergy, Asthma & Immunology Research·Jian-Feng Meng, Lanny J Rosenwasser
Aug 21, 2010·Current Opinion in Allergy and Clinical Immunology·Daniel T Swarr, Hakon Hakonarson

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