Genetic interactions: the missing links for a better understanding of cancer susceptibility, progression and treatment

Molecular Cancer
Christopher A MaxwellMiguel Angel Pujana

Abstract

It is increasingly clear that complex networks of relationships between genes and/or proteins govern neoplastic processes. Our understanding of these networks is expanded by the use of functional genomic and proteomic approaches in addition to computational modeling. Concurrently, whole-genome association scans and mutational screens of cancer genomes identify novel cancer genes. Together, these analyses have vastly increased our knowledge of cancer, in terms of both "part lists" and their functional associations. However, genetic interactions have hitherto only been studied in depth in model organisms and remain largely unknown for human systems. Here, we discuss the importance and potential benefits of identifying genetic interactions at the human genome level for creating a better understanding of cancer susceptibility and progression and developing novel effective anticancer therapies. We examine gene expression profiles in the presence and absence of co-amplification of the 8q24 and 20q13 chromosomal regions in breast tumors to illustrate the molecular consequences and complexity of genetic interactions and their role in tumorigenesis. Finally, we highlight current strategies for targeting tumor dependencies and outline po...Continue Reading

References

Sep 1, 1992·Trends in Genetics : TIG·L Avery, S Wasserman
Oct 7, 1994·Science·P A FutrealY Miki
Oct 25, 1996·Science·A GoffeauS G Oliver
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Aug 10, 2000·Nature·R AlbertA L Barabasi
Mar 10, 2001·Science·J L HartmanL Hartwell
May 18, 2001·Nature·J H Hoeijmakers
Feb 28, 2002·American Journal of Epidemiology·W James Gauderman
Mar 2, 2002·Science·Hiroaki Kitano
Mar 2, 2002·Science·Marie E Csete, John C Doyle
Jun 28, 2002·Cancer Cell·Douglas R Green, Gerard I Evan
Apr 2, 2003·Human Molecular Genetics·Chu-Xia Deng, Rui-Hong Wang
Oct 31, 2003·American Journal of Epidemiology·Shuang Wang, Hongyu Zhao
Nov 14, 2003·Nature·Hiroaki Kitano
Jan 22, 2004·Nature Reviews. Genetics·Krina T Zondervan, Lon R Cardon
Jan 22, 2004·Nature Reviews. Genetics·Albert-László Barabási, Zoltán N Oltvai
Feb 7, 2004·Science·Amy Hin Yan TongCharles Boone
Mar 3, 2004·Nature Reviews. Cancer·Hiroaki Kitano
Mar 26, 2004·Nature·Patrick J PaddisonGregory J Hannon
Aug 12, 2004·Genetic Epidemiology·Robert CulverhouseWilliam Shannon
Sep 29, 2004·Current Opinion in Microbiology·Timothy R HughesMark Johnston
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Elena SanchoHans Clevers
Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sharyl L WongFrederick P Roth
Dec 14, 2004·Nature Genetics·Daniel SegrèRoy Kishony
Dec 21, 2004·Current Opinion in Oncology·I G Khalil, C Hill
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Roded SharanTrey Ideker
Apr 19, 2005·Genome Biology·Becky L DreesTimothy Galitski
May 7, 2005·Nature Biotechnology·Ryan Kelley, Trey Ideker
May 28, 2005·Nature Genetics·Daniel R Rhodes, Arul M Chinnaiyan
Sep 13, 2005·Nature Genetics·Armaity P DavierwalaTimothy R Hughes
Oct 4, 2005·Nature Genetics·Jose M SilvaGregory J Hannon
Jan 20, 2006·Genome Biology·Chad L MyersOlga G Troyanskaya
Jan 20, 2006·British Journal of Cancer·S ForbesM R Stratton

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Citations

Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Scott J DixonCharles Boone
Jun 18, 2010·Bioinformatics·John M O RanolaKenneth Lange

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