Genetic interferonopathies: An overview

Best Practice & Research. Clinical Rheumatology
Despina Eleftheriou, Paul A Brogan

Abstract

Interferonopathies comprise an expanding group of monogenic diseases characterised by disturbance of the homeostatic control of interferon (IFN)-mediated immune responses. Although differing in the degree of phenotypic expression and severity, the clinical presentation of these diseases shows a considerable degree of overlap, reflecting their common pathogenetic mechanisms. Increased understanding of the molecular basis of these Mendelian disorders has led to the identification of targeted therapies for these diseases, which could also be of potential relevance for non-genetic IFN-mediated diseases such as systemic lupus erythematosus and juvenile dermatomyositis. In this paper, we summarise the current knowledge of the molecular basis, clinical features and the treatment available for monogenic interferonopathies.

Citations

Jan 11, 2020·Frontiers in Pediatrics·Sara MatricardiAlberto Verrotti
Jul 28, 2020·British Journal of Haematology·Pietro MerliStefania Gaspari
Oct 21, 2020·Nature Reviews. Drug Discovery·Ali A ZarrinDomagoj Vucic
Oct 22, 2020·Expert Opinion on Biological Therapy·Bethan Goulden, David Isenberg
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May 11, 2021·Frontiers in Neurology·Diane BeysenMarije M E Meuwissen
Apr 20, 2021·Journal of Clinical Pharmacology·Sara AssadiaslMohammad Hossein Nicknam
Nov 9, 2021·The British Journal of Dermatology·S M Pilkington, R E B Watson

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