Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program

Genes & Development
Anna E MazzuccoStephen J Elledge

Abstract

Senescence is a terminal differentiation program that halts the growth of damaged cells and must be circumvented for cancer to arise. Here we describe a panel of genetic screens to identify genes required for replicative senescence. We uncover a role in senescence for the potent tumor suppressor and ATM substrate USP28. USP28 controls activation of both the TP53 branch and the GATA4/NFkB branch that controls the senescence-associated secretory phenotype (SASP). These results suggest a role for ubiquitination in senescence and imply a common node downstream from ATM that links the TP53 and GATA4 branches of the senescence response.

References

Jul 1, 1992·Experimental Gerontology·W E Wright, J W Shay
Jan 1, 1996·Experimental Gerontology·J CampisiK Yoshimoto
Sep 1, 1997·Trends in Genetics : TIG·M Kanehisa
Mar 30, 2002·Science·Jan KarlsederTitia de Lange
Aug 10, 2002·The EMBO Journal·Agata Smogorzewska, Titia de Lange
Aug 13, 2003·The EMBO Journal·Christian M BeauséjourJudith Campisi
Aug 6, 2005·Science·Judith Campisi
Dec 1, 2006·Nature·Raffaella Di MiccoFabrizio d'Adda di Fagagna
Dec 13, 2006·Cancer Cell·Stéphanie Courtois-CoxKaren Cichowski
Jun 15, 2007·Nature Cell Biology·Nikita PopovMartin Eilers
Dec 18, 2007·The Journal of Biological Chemistry·Jed LongMark S Searle
Feb 2, 2008·Science·Michael R SchlabachStephen J Elledge
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Arturo V OrjaloJudith Campisi
Feb 19, 2010·Nature·Rameen BeroukhimMatthew Meyerson
Oct 19, 2010·Nucleic Acids Research·Simon A ForbesP Andrew Futreal
Jun 8, 2011·Genes & Development·Mickaël OhannaCorine Bertolotto
Feb 4, 2016·Nature·Darren J BakerJan M van Deursen

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Citations

Dec 22, 2019·Cells·Tsung-Cheng LinHung-Chi Cheng
May 22, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kehong ChenYani He
Feb 6, 2019·Molecular Medicine Reports·Jing ChenRobert G Hawley
Jan 11, 2020·Computational and Structural Biotechnology Journal·Paula Santos-OtteStuart Maudsley
Dec 18, 2020·Nature Reviews. Molecular Cell Biology·Raffaella Di MiccoFabrizio d'Adda di Fagagna
Mar 5, 2021·Aging Cell·Yahya BenslimaneLea Harrington
Apr 8, 2021·Circulation Research·Ryan M BurkeEric M Small

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