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Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B

European Journal of Human Genetics : EJHG

May 17, 2012

Friederike FlachsbartAlmut Nebel

Abstract

Our study demonstrates that the genetic investigation of forkhead box O3A gene (FOXO3A), a validated human longevity gene, is greatly hampered by the fact that its exonic regions have 99% sequence homology with the FOXO3B pseudogene. If unaccounted for, this high degree of homology can ...read more

Mentioned in this Paper

FOXO3B gene
Assay
Sequencing
Longevity
Nucleotides
Genetic Polymorphism
Pseudogenes
FOXO3 wt Allele
3' Untranslated Regions
Single Nucleotide Polymorphism
Paper Details
References
  • References16
  • Citations3
12

Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B

European Journal of Human Genetics : EJHG

May 17, 2012

Friederike FlachsbartAlmut Nebel

PMID: 22588664

DOI: 10.1038/ejhg.2012.83

Abstract

Our study demonstrates that the genetic investigation of forkhead box O3A gene (FOXO3A), a validated human longevity gene, is greatly hampered by the fact that its exonic regions have 99% sequence homology with the FOXO3B pseudogene. If unaccounted for, this high degree of homology can ...read more

Mentioned in this Paper

FOXO3B gene
Assay
Sequencing
Longevity
Nucleotides
Genetic Polymorphism
Pseudogenes
FOXO3 wt Allele
3' Untranslated Regions
Single Nucleotide Polymorphism

Related Papers

Paper Details
References
  • References16
  • Citations3
12
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