Genetic Labeling of Car4-expressing Cells Reveals Subpopulations of Type III Taste Cells

Chemical Senses
Kristina LossowWolfgang Meyerhof

Abstract

Carbonic anhydrases form an enzyme family of 16 members, which reversibly catalyze the hydration of carbon dioxide to bicarbonate and protons. In lung, kidney, and brain, presence of carbonic anhydrases is associated with protons and bicarbonate transport in capillary endothelium of lung, reabsorption of bicarbonate in proximal renal tubules, and extracellular buffering. In contrast, their role in taste is less clear. Recently, carbonic anhydrase IV expression was detected in sour-sensing presynaptic taste cells and was associated with the taste of carbonation, yet the precise role and cell population remained uncertain. To examine the role of carbonic anhydrase 4-expressing cells in taste reception, we generated a mouse strain carrying a modified allele of the carbonic anhydrase 4 gene in which the coding region of the red fluorescent protein monomeric Cherry is attached to that of carbonic anhydrase 4 via an internal ribosome entry site. Monomeric Cherry fluorescence was detected in lingual papillae as well as taste buds of soft palate and naso-incisor duct. However, expression patterns on the tongue differ between posterior and fungiform papillae. Whereas monomeric Cherry auto-fluorescence was almost always co-localized with...Continue Reading

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Citations

May 1, 2019·Chemical Senses·Christopher T SimonsEarl Carstens
Jun 26, 2020·Chemical Senses·Aurelie VandenbeuchSue C Kinnamon
Sep 2, 2020·International Journal of Molecular Sciences·Mohammad Zakir HossainJunichi Kitagawa
Feb 2, 2020·Chemical Senses·Kristina LossowMaik Behrens
Jan 30, 2019·Neural Development·Jennifer Rios-Pilier, Robin F Krimm
Dec 2, 2020·International Journal of Molecular Sciences·Ayana OsakiNoriatsu Shigemura
Feb 23, 2021·Current Opinion in Physiology·Thomas E Finger, Linda A Barlow
Apr 4, 2021·Metabolites·Sonali Puri, Youngseok Lee
May 5, 2021·Cell and Tissue Research·Eriko Koyanagi-MatsumuraShuitsu Harada

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