Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemia

Genes, Chromosomes & Cancer
Sharon W HorsleyLyndal Kearney

Abstract

In a small fraction ( approximately 2%) of cases of childhood acute lymphoblastic leukemia (ALL) clinical presentation of leukemia is preceded, some 2-9 months earlier, by a transient, remitting phase of nonclassical aplastic anemia, usually in connection with infection. The potential "preleukemic" nature of this prodromal phase has not been fully explored. We have retrospectively analyzed the blood and bone marrow of a child who presented with aplastic anemia 9 months before the development of ETV6-RUNX1 fusion gene positive ALL. High resolution SNP genotyping arrays identified 11 regions of loss of heterozygosity, with and without concurrent copy number changes, at the presentation of ALL. In all cases of copy number change, the deletion or gain identified by single nucleotide polymorphism (SNP) analysis was confirmed in the ALL blasts by FISH. Retrospective analysis of aplastic phase bone marrow showed that the ETV6-RUNX1 fusion was present along with all of the additional genetic changes assessed, albeit subclonal to ETV6-RUNX1. These data identify for the first time the leukemic genotype of an aplasia preceding clinical ALL and indicate that multiple secondary genetic abnormalities can contribute to a dominant subclone sev...Continue Reading

References

Aug 1, 1992·Journal of Clinical Pathology·M M Reid, G P Summerfield
Jan 1, 1988·Leukemia Research·R IrelandG Mufti
Jan 1, 1985·The American Journal of Pediatric Hematology/oncology·G BevilacquaP Macchia
Jan 1, 1984·The American Journal of Pediatric Hematology/oncology·U M Saarinen, R Wegelius
Jul 1, 1981·Cancer·R H Sills, J A Stockman
Nov 1, 1981·British Journal of Haematology·F BreatnachM F Greaves
Sep 21, 2001·British Journal of Haematology·E D HeegaardK Schmiegelow
Jun 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi MoriMel Greaves
Jun 7, 2003·Blood·Mel F GreavesAnthony M Ford
Sep 3, 2003·Nature Reviews. Cancer·Mel F Greaves, Joe Wiemels
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jan ZunaMel Greaves
Feb 10, 2006·Nature Reviews. Cancer·Mel Greaves
Mar 9, 2007·Nature·Christopher GreenmanMichael R Stratton
Mar 9, 2007·Nature·Charles G MullighanJames R Downing

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Citations

Dec 14, 2011·Hematology·Charlotte M Niemeyer, Irith Baumann
Oct 11, 2012·Revista brasileira de hematologia e hemoterapia·Laura Villarreal-MartínezDavid Gómez-Almaguer
Sep 24, 2013·Genome Research·Nicola E PotterMel Greaves
Dec 24, 2014·Stem Cell Reports·Sara G M PiccirilloMel Greaves
Oct 22, 2008·Genes, Chromosomes & Cancer·Jan ZunaJan Trka
Aug 4, 2015·Stem Cells International·Fabian LangMichael A Rieger
Dec 30, 2017·Oncology Letters·Timm HöresKerstin Schaefer-Eckart

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