PMID: 11606002Oct 19, 2001Paper

Genetic liability, illicit drug use, life stress and psychotic symptoms: preliminary findings from the Edinburgh study of people at high risk for schizophrenia

Social Psychiatry and Psychiatric Epidemiology
P MillerE C Johnstone

Abstract

Studies of groups at high risk of developing schizophrenia have tended to be based on subjects recruited to the study in their infancy. This paper reports on subjects at genetic high risk for schizophrenia assessed as young adults, close to the age when most onsets of schizophrenia occur. One hundred and fifty-five young people at elevated risk for the development of schizophrenia and 36 controls not at increased risk were assessed on entry to the Edinburgh High Risk Study. The measures included current psychotic symptoms, past and present cannabis and other drug use, lifetime life events and two aspects of genetic liability to schizophrenia. Cannabis and other illicit drug use were significantly associated with symptoms in both groups. The same held true for the more upsetting life events experienced, but not for less upsetting ones. Within the high-risk group, there was no relationship between symptoms and a measure of genetic loading, but there was some slight evidence of a higher risk of symptoms when affected relatives were on the father's rather than the mother's side of the family. Cannabis use, use of other illicit substances and upsetting life events may all lead to psychotic symptoms in vulnerable young people.

Citations

Jun 26, 2008·Social Psychiatry and Psychiatric Epidemiology·Wim VelingJohan P Mackenbach
Jul 18, 2009·European Archives of Psychiatry and Clinical Neuroscience·Deepak Cyril D'SouzaMohini Ranganathan
May 11, 2002·Current Psychiatry Reports·Louisa Degenhardt, Wayne Hall
Sep 18, 2004·Schizophrenia Research·Thomas J DinzeoNancy M Docherty
Sep 6, 2003·Pharmacology, Biochemistry, and Behavior·David M SempleAndrew M McIntosh
Jan 7, 2006·Epidemiologia e psichiatria sociale·Marta Di Forti, Robin McGregor Murray
Jul 7, 2011·Behavioural and Cognitive Psychotherapy·Lisa Jane PhillipsShona Francey
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Jan 21, 2006·BMJ : British Medical Journal·David M FergussonJoseph M Boden
Jul 1, 2013·Journal of Child and Adolescent Mental Health·Saeeda ParukRochelle Caplan
Dec 17, 2009·The Australian and New Zealand Journal of Psychiatry·Bart D PetersLieuwe de Haan
Mar 15, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Alexis E CullenKristin R Laurens
Jul 24, 2014·Psychological Medicine·L R ValmaggiaP K McGuire
Jul 2, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Jai ShahKwame McKenzie
Jan 26, 2016·Biological Psychiatry·Cynthia Shannon WeickertDuncan Sinclair
Feb 25, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Amy F T Arnsten
Sep 21, 2010·Journal of Psychiatric Research·Alex S CohenDiana W Stewart
Jun 12, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Patrik RoserAndreas M Stadelmann
Oct 16, 2007·Schizophrenia Research·Dagmar VersmissenLydia Krabbendam
Sep 22, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·R E FeatherstoneP J Fletcher
Mar 16, 2007·Acta Psychiatrica Scandinavica·J Addington, D Addington
Jun 29, 2013·The American Journal on Addictions·Alexander BaldacchinoIlana B Crome
Sep 23, 2014·Early Intervention in Psychiatry·Susana Marulanda, Jean Addington
Jun 12, 2010·Early Intervention in Psychiatry·Sheri MadraisauHilda Ngiralmau
Jan 12, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Stephan RuhrmannJoachim Klosterkötter
Sep 6, 2005·Schizophrenia Research·Matcheri S KeshavanJohn A Sweeney
Apr 3, 2016·Early Intervention in Psychiatry·Saeeda ParukJonathan K Burns
Dec 16, 2006·Clinical Psychology Review·Lisa J PhillipsNancy McMurray
Nov 20, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zoltan MakkosJudit Lazary
Dec 23, 2004·Journal of Pharmacological Sciences·Hiroshi Ujike, Yukitaka Morita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.