Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart

Cardiovascular Research
Lingjuan HeBin Zhou

Abstract

Capillary and arterial endothelial cells share many common molecular markers in both the neonatal and adult hearts. Herein, we aim to establish a genetic tool that distinguishes these two types of vessels in order to determine the cellular mechanism underlying collateral artery formation. Using Apln-GFP and Apln-LacZ reporter mice, we demonstrate that APLN expression is enriched in coronary vascular endothelial cells. However, APLN expression is reduced in coronary arterial endothelial cells. Genetic lineage tracing, using an Apln-CreER mouse line, robustly labelled capillary endothelial cells, but not arterial endothelial cells. We leveraged this differential activity of Apln-CreER to study collateral artery formation following myocardial infarction (MI). In a neonatal heart MI model, we found that Apln-CreER-labelled capillary endothelial cells do not contribute to the large collateral arteries. Instead, these large collateral arteries mainly arise from pre-existing, infrequently labelled coronary arteries, indicative of arteriogenesis. Furthermore, in an adult heart MI model, Apln-CreER activity also distinguishes large and small diameter arteries from capillaries. Lineage tracing in this setting demonstrated that most large...Continue Reading

References

Nov 8, 1974·Deutsche medizinische Wochenschrift·W Schaper
Nov 1, 1996·Circulation Research·W Schaper, W D Ito
Feb 14, 1998·The Journal of Clinical Investigation·M ArrasW Schaper
Sep 8, 1998·Journal of Applied Physiology·F C WhiteS M Carroll
Feb 13, 2001·Developmental Biology·Y Y KisanukiM Yanagisawa
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Sandra HerzogWulf D Ito
Mar 1, 2003·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Armin Helisch, Wolfgang Schaper
Feb 2, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jackelyn A AlvaM Luisa Iruela-Arispe
Oct 31, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Arnaud MonvoisinM Luisa Iruela-Arispe
Feb 20, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Petra RocicWilliam M Chilian
Mar 3, 2007·The Journal of Clinical Investigation·Bradford C BerkStephanie Lehoux
Mar 8, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Veli-Pekka RonkainenPasi Tavi
Apr 7, 2007·Developmental Biology·Roland E KälinAndré W Brändli
Aug 28, 2007·Cell·Sunyoung LeeM Luisa Iruela-Arispe
Oct 2, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Ahmad Y SheikhThomas Quertermous
Apr 4, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Souad BelmadaniWilliam M Chilian
Sep 22, 2009·American Journal of Physiology. Heart and Circulatory Physiology·David N CharoThomas Quertermous
Mar 26, 2010·Nature·Kristy Red-HorseMark A Krasnow
Mar 10, 2011·Cardiovascular Research·Lucile MiquerolRobert G Kelly
Apr 21, 2011·The Journal of Clinical Investigation·Bin ZhouWilliam T Pu
Jan 24, 2012·Cell·Kai Kretzschmar, Fiona M Watt
May 23, 2012·Blood·Qing C YuAndrew G Elefanty
Feb 14, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Gabor M Rubanyi
Aug 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mei XinEric N Olson
Jul 12, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·James E FaberMichael Simons
Oct 1, 2014·Journal of Cellular and Molecular Medicine·Lingjuan HeBin Zhou
Jan 20, 2015·Nature Communications·Qiaozhen LiuBin Zhou
Jan 31, 2015·Circulation Research·Xueying TianBin Zhou

❮ Previous
Next ❯

Citations

Sep 24, 2016·Cardiovascular Research·Raffaele AltaraGeorge W Booz
Apr 6, 2017·The Journal of Biological Chemistry·Yue WangBin Zhou
Jul 22, 2017·Nature Reviews. Drug Discovery·Thomas J CahillPaul R Riley
Dec 1, 2017·Cardiovascular Research·Diane GalWouter Vandevelde
Nov 14, 2017·Nature Medicine·Lingjuan HeBin Zhou
Nov 20, 2016·Nature Communications·Wenjuan PuBin Zhou
Oct 23, 2019·Cold Spring Harbor Perspectives in Biology·Lingjuan HeBin Zhou
May 8, 2020·Circulation Research·Antonio CannatàMauro Giacca
Jun 27, 2020·Nature Reviews. Cardiology·Irina-Elena LupuNicola Smart
Nov 20, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Nicola Smart
Nov 6, 2020·Circulation Research·Maoying Han, Bin Zhou
Oct 11, 2020·Journal of Molecular and Cellular Cardiology·Amir AghajanianJames E Faber
Jan 31, 2020·Cardiovascular Research·Tea KocijanSerena Zacchigna
Mar 4, 2021·Current Cardiology Reports·Kristy Red-Horse, Soumyashree Das
May 14, 2021·IScience·Hana KolesováDavid Sedmera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society
I Buschmann, Wolfgang Schaper
© 2022 Meta ULC. All rights reserved