Genetic linkage and natural selection.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
N H Barton

Abstract

The prevalence of recombination in eukaryotes poses one of the most puzzling questions in biology. The most compelling general explanation is that recombination facilitates selection by breaking down the negative associations generated by random drift (i.e. Hill-Robertson interference, HRI). I classify the effects of HRI owing to: deleterious mutation, balancing selection and selective sweeps on: neutral diversity, rates of adaptation and the mutation load. These effects are mediated primarily by the density of deleterious mutations and of selective sweeps. Sequence polymorphism and divergence suggest that these rates may be high enough to cause significant interference even in genomic regions of high recombination. However, neither seems able to generate enough variance in fitness to select strongly for high rates of recombination. It is plausible that spatial and temporal fluctuations in selection generate much more fitness variance, and hence selection for recombination, than can be explained by uniformly deleterious mutations or species-wide selective sweeps.

References

Sep 1, 1978·Scientific American·J M Smith
Oct 1, 1978·Theoretical Population Biology·J Haigh
Jun 20, 1991·Nature·J H McDonald, M Kreitman
Feb 1, 1988·Genetical Research·J M Smith
Feb 1, 1987·Heredity·D A Roff, T A Mousseau
Feb 1, 1974·Genetical Research·J M Smith, J Haigh
Oct 1, 1974·Genetics·J Felsenstein
Jun 1, 1971·Theoretical Population Biology·M Kimura
Dec 1, 1966·Genetical Research·W G Hill, A Robertson
Jun 1, 1995·Genetics·N H Barton
Apr 1, 1995·International Journal of Food Microbiology·G G Greer, B D Dilts
Jun 1, 1993·Genetical Research·B Charlesworth
Dec 1, 1995·Genetics·R R Hudson, N L Kaplan
Apr 1, 1996·Genetical Research·M NordborgD Charlesworth
Apr 1, 1996·Theoretical Population Biology·T Ohta, J H Gillespie
Jan 1, 1996·Annual Review of Genetics·M W FeldmanF B Christiansen
Aug 1, 1997·Genetical Research·B Charlesworth, D Charlesworth
Feb 5, 1998·Journal of the National Cancer Institute·J ApplebaumJ C Bystryn
Mar 16, 2000·The American Naturalist·J Merilä, B C Sheldon
Aug 11, 2000·Evolution; International Journal of Organic Evolution·R R RegoesS Bonhoeffer
Aug 11, 2000·Evolution; International Journal of Organic Evolution·A Burt
Sep 6, 2000·Proceedings. Biological Sciences·P K Ingvarsson, M C Whitlock
Sep 9, 2000·Genetics·T Lenormand, S P Otto
Mar 7, 2001·Cellular and Molecular Life Sciences : CMLS·D I Nurminsky
Mar 31, 2001·Genetical Research·P AndolfattoA Navarro
Jan 5, 2002·Evolution; International Journal of Organic Evolution·S P Otto, N H Barton
Jan 17, 2002·Evolution; International Journal of Organic Evolution·J H Gillespie
Feb 28, 2002·Archives of Internal Medicine·Ralph Snyderman, Andrew T Weil
Mar 5, 2002·Nature·Nick G C Smith, Adam Eyre-Walker
Jun 20, 2002·Genetics·Arcadio Navarro, Nick H Barton
Jul 27, 2002·Annual Review of Microbiology·Frederick M Cohan
Sep 21, 2002·Genetics·Toby Johnson, Nick H Barton

❮ Previous
Next ❯

Citations

Mar 25, 2011·Genetics Research·Brian Charlesworth
Mar 13, 2013·Nature Reviews. Genetics·Asher D Cutter, Bret A Payseur
Jun 19, 2013·Nucleic Acids Research·Antonio MarcoSam Griffiths-Jones
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Bonsall, Brian Charlesworth
Jul 5, 2013·PloS One·Damien M de ViennePierre-Henri Gouyon
Jul 16, 2011·Annual Review of Genomics and Human Genetics·Michael LynchMina Rho
Sep 25, 2014·Annual Review of Genetics·Brian Charlesworth, José L Campos
Mar 13, 2014·Genetics·Simon Aeschbacher, Reinhard Bürger
Jul 21, 2016·Current Opinion in Insect Science·Carlos F AriasW Owen McMillan
Feb 26, 2016·Journal of Theoretical Biology·Jeremy Van Cleve
May 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Zoe June AssafJamie R Blundell
Sep 29, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Asher D Cutter, Richard Jovelin
Jun 14, 2012·Integrative Zoology·Matthew Hartfield, Peter D Keightley
Dec 5, 2012·Evolution; International Journal of Organic Evolution·Matthew HartfieldPeter D Keightley
Jun 12, 2013·Communicative & Integrative Biology·Clement F Kent, Amro Zayed
Oct 24, 2013·Trends in Ecology & Evolution·Robert LanfearAdam Eyre-Walker
Dec 3, 2014·Journal of Theoretical Biology·Sona John, Kavita Jain
Sep 9, 2011·PLoS Genetics·Sung Chun, Justin C Fay
Mar 8, 2007·PloS One·Tim van OpijnenBen Berkhout
Jun 16, 2010·PLoS Computational Biology·Eamon B O'DeaClaus O Wilke
Dec 19, 2006·PLoS Genetics·Pleuni S Pennings, Joachim Hermisson
Mar 9, 2011·PLoS Genetics·Benjamin CallahanBoris I Shraiman
Sep 19, 2014·PLoS Computational Biology·Stefan NowakJoachim Krug
Jul 28, 2016·Heredity·B Charlesworth, D Charlesworth
Jul 21, 2016·Molecular Biology and Evolution·Tobias L LenzShamil R Sunyaev
Apr 30, 2008·Theoretical Population Biology·Denis Roze, François Rousset
Mar 16, 2017·Journal of Evolutionary Biology·J da Silva, J D Galbraith
Apr 28, 2018·PLoS Genetics·Kathleen SprouffskeAndreas Wagner
Mar 30, 2019·Genetics·José Luis Campos, Brian Charlesworth
Jan 14, 2018·Genetics·Brian J ArnoldWilliam P Hanage
Dec 7, 2019·American Journal of Botany·Adriana López-Villalobos, Christopher G Eckert
Mar 14, 2020·Annals of Botany·Karolina HeydukJim Leebens-Mack
Jun 28, 2012·PLoS Pathogens·Mark AchtmanUNKNOWN S. Enterica MLST Study Group
Jun 2, 2017·Proceedings. Biological Sciences·Deborah CharlesworthBrian Charlesworth
Jun 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·José Luis CamposBrian Charlesworth
Nov 20, 2018·Nature Communications·Bridgett M vonHoldtThomas B Smith
Mar 9, 2017·Genetics·Sònia Casillas, Antonio Barbadilla
Sep 1, 2017·Genome Biology and Evolution·Louise OrmondJennifer P Wang
Aug 3, 2019·Nature Communications·Alexander MackintoshKonrad Lohse
Mar 23, 2018·Journal of the Royal Society, Interface·Victor GarciaMarcus W Feldman
Oct 7, 2018·Genome Biology·Katie E LotterhosKathryn A Hodgins
Dec 15, 2017·Journal of Genetics·Brian Charlesworth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cold Spring Harbor Symposia on Quantitative Biology
B CharlesworthIsabel Gordo
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
N H Barton
Evolution; International Journal of Organic Evolution
Sarah P Otto, N H Barton
© 2021 Meta ULC. All rights reserved