Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease

Cytokine
Olga McLeodIMPROVE Study Group

Abstract

IL-5 is a Th2 cytokine which activates eosinophils and is suggested to have an atheroprotective role. Genetic variants in the IL5 locus have been associated with increased risk of CAD and ischemic stroke. In this study we aimed to identify genetic variants associated with IL-5 concentrations and apply a Mendelian randomisation approach to assess IL-5 levels for causal effect on intima-media thickness in a European population at high risk of coronary artery disease. We analysed SNPs within robustly associated candidate loci for immune, inflammatory, metabolic and cardiovascular traits. We identified 2 genetic loci for IL-5 levels (chromosome 5, rs56183820, BETA=0.11, P=6.73E(-5) and chromosome 14, rs4902762, BETA=0.12, P=5.76E(-6)) and one for eosinophil count (rs72797327, BETA=-0.10, P=1.41E(-6)). Both chromosome 5 loci were in the vicinity of the IL5 gene, however the association with IL-5 levels failed to replicate in a meta-analysis of 2 independent cohorts (rs56183820, BETA=0.04, P=0.2763, I(2)=24, I(2)-P=0.2516). No significant associations were observed between SNPs associated with IL-5 levels or eosinophil count and IMT measures. Expression quantitative trait analyses indicate effects of the IL-5 and eosinophil-associate...Continue Reading

References

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Citations

Oct 21, 2016·Expert Review of Clinical Immunology·Meritxell Nus, Ziad Mallat
Feb 23, 2017·Allergy·S Prakash BabuA D Klion
Oct 26, 2018·Circulation·Giampaolo NiccoliFilippo Crea
Apr 16, 2021·ERJ Open Research·Mathieu FieldesArnaud Bourdin
Aug 28, 2021·International Journal of Molecular Sciences·Anastasia V PoznyakAlexander N Orekhov

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Methods Mentioned

BETA
chip
chips
PROCARDIS
sandwich immunoassay
genotyping
MDS
biopsy

Software Mentioned

PLINK
MuTHER
IMPROVE
STATA

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