Genetic loci that control the angiogenic response to basic fibroblast growth factor

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Michael S RogersRobert J D'Amato

Abstract

Angiogenesis is controlled by a balance between stimulatory growth factors and endogenous inhibitors. We propose that the balance of stimulators and inhibitors, as well as the general sensitivity of the endothelium to these factors, varies from individual to individual. Indeed, we have found that individual mouse strains have dramatically different responses to growth factor-induced neovascularization. Quantitative trait loci (QTLs), which influence the extent of angiogenesis induced by vascular endothelial growth factor (VEGF), were previously identified by our laboratory. Since genetic susceptibility may vary according to the angiogenic stimulator, we have undertaken a similar mapping approach to identify QTLs that influence basic fibroblast growth factor (FGF2) induced neovascularization in the BXD series of recombinant inbred mouse strains. Composite and multiple interval mapping identified areas of chromosomes 4, 13, 15, and 18. These new angiogenesis QTLs, named AngFq1 through AngFq4 (for angiogenesis due to FGF2), are different from previously identified VEGF QTLs. The mapped regions contain several genes involved in the angiogenic process including matrix metalloproteinase 16, eph receptor A7, angiopoetin 1, endothelial...Continue Reading

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Citations

Aug 10, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sharolyn V Kawakami-SchulzSakae Ikeda
Feb 21, 2013·Angiogenesis·Michael S RogersRobert J D'Amato
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