Genetic mapping of a 17q chromosomal region linked to obesity phenotypes in the IRAS family study

International Journal of Obesity : Journal of the International Association for the Study of Obesity
B S SuttonD W Bowden

Abstract

Obesity is widely accepted to be influenced by both environmental and genetic factors. Several recent studies have used the positional cloning approach in an attempt to discover genes contributing to obesity. In the IRAS Family Study a genomewide scan was performed on 1425 individuals of Hispanic descent (90 extended pedigree families) to identify regions of the genome linked to obesity phenotypes. Nonparametric QTL linkage analysis was performed using a variance components approach. The genome scan was performed in two phases: an initial genome scan in 45 families and a replication scan in 45 families. Fine mapping and candidate gene analyses were also performed. General estimating equations (GEE1) and quantitative pedigree disequilibrium tests (QPDT) were used for association analysis of single SNP and haplotype data. Evidence for linkage to obesity traits was observed in each scan on the long arm of chromosome 17. When data from both scans was combined, a region on chromosome 17q was identified with evidence of linkage to visceral adipose tissue (VAT; LOD 3.11), waist circumference (WAIST) (LOD 2.5) and body mass index (BMI) (LOD 2.81). Nine additional microsatellite markers were identified and genotyped on all Hispanic indi...Continue Reading

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Citations

Nov 21, 2015·Experimental Gerontology·Penghua FangZhenwen Zhang
Dec 24, 2015·Diabetology & Metabolic Syndrome·Bruna Bellincanta Nicoletto, Luis Henrique Canani
Jul 7, 2009·American Journal of Human Genetics·Amy MurphyJuan C Celedón
Sep 18, 2014·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Tom G RichardsonDavid Wynick
Oct 31, 2006·Oncogene·K De BosscherG Haegeman
Oct 28, 2019·Pharmacogenetics and Genomics·Henrik Thyge Corfitsen, Antonio Drago

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