Genetic mapping of social interaction behavior in B6/MSM consomic mouse strains.

Behavior Genetics
Aki TakahashiTsuyoshi Koide

Abstract

Genetic studies are indispensable for understanding the mechanisms by which individuals develop differences in social behavior. We report genetic mapping of social interaction behavior using inter-subspecific consomic strains established from MSM/Ms (MSM) and C57BL/6J (B6) mice. Two animals of the same strain and sex, aged 10 weeks, were introduced into a novel open-field for 10 min. Social contact was detected by an automated system when the distance between the centers of the two animals became less than approximately 12 cm. In addition, detailed behavioral observations were made of the males. The wild-derived mouse strain MSM showed significantly longer social contact as compared to B6. Analysis of the consomic panel identified two chromosomes (Chr 6 and Chr 17) with quantitative trait loci (QTL) responsible for lengthened social contact in MSM mice and two chromosomes (Chr 9 and Chr X) with QTL that inhibited social contact. Detailed behavioral analysis of males identified four additional chromosomes associated with social interaction behavior. B6 mice that contained Chr 13 from MSM showed more genital grooming and following than the parental B6 strain, whereas the presence of Chr 8 and Chr 12 from MSM resulted in a reducti...Continue Reading

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Citations

Oct 5, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Akinori NishiTsuyoshi Koide
Sep 11, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Joseph H NadeauToshihiko Shiroishi
Apr 23, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Mai NakaharaKimi Araki
Nov 13, 2015·The Journal of Reproduction and Development·Natsumi EndoTomomi Tanaka
Jul 28, 2011·Experimental Animals·Tsuyoshi KoideAki Takahashi
Jan 27, 2015·Neuroscience Bulletin·Young-A Lee, Yukiori Goto
Mar 14, 2018·Genetics·Martin JohnssonDominic Wright
Sep 1, 2017·G3 : Genes - Genomes - Genetics·Taro KataokaToshihiko Shiroishi
May 4, 2010·The Journal of Experimental Biology·Harold DowseTsuyoshi Koide
Mar 30, 2021·Experimental Animals·Kazuhiro OkumuraYuichi Wakabayashi

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