PMID: 6167540Jul 1, 1980Paper

Genetic mapping of the hemochromatosis locus on chromosome six

Human Immunology
C Q EdwardsD B Amos

Abstract

The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, B7 and A28, B12 haplotypes. The hemochromatosis locus segregated with the HLA-A locus and not with the HLA-B locus. Thus, the hemochromatosis locus maps in close proximity to the HLA-A locus.

References

Aug 1, 1976·The Journal of Experimental Medicine·F H BachM L Bach
Jul 26, 1979·The New England Journal of Medicine·G E CartwrightL Buskjaer
May 1, 1978·Tissue Antigens·M LipinskiJ Dausset
Jul 7, 1977·The New England Journal of Medicine·C Q EdwardsG E Cartwright

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Citations

Oct 10, 1985·The New England Journal of Medicine·L R Weitkamp, B Z Schacter
Jun 3, 1993·The New England Journal of Medicine·C Q Edwards, J P Kushner
Dec 3, 2014·Clinics in Liver Disease·Reena J Salgia, Kimberly Brown
Jan 1, 1992·Baillière's Clinical Haematology·V R Gordeuk
Jan 1, 1988·Annals of the New York Academy of Sciences·C Q EdwardsJ P Kushner
Jan 1, 1994·Critical Reviews in Clinical Laboratory Sciences·V R GordeukW Samowitz
Aug 1, 1987·Biological Trace Element Research·D J VauxF Watt
Jan 1, 1983·Critical Reviews in Clinical Laboratory Sciences·G D McLarenR W Kellermeyer
Sep 1, 1982·American Journal of Hematology·C Q EdwardsJ P Kushner
May 26, 1988·The New England Journal of Medicine·C Q EdwardsJ P Kushner
Apr 1, 1997·The Australian and New Zealand Journal of Psychiatry·J P DavisH Herrman
Jan 1, 1988·Annals of the New York Academy of Sciences·C Q EdwardsJ P Kushner
Feb 1, 1989·European Journal of Haematology·T M Cox, D K Lord
Apr 1, 1988·Clinical Genetics·N MilmanK Fenger
Nov 1, 1995·Annals of Clinical Biochemistry·D K GeorgeI R Gunn
Feb 28, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·D L WitteF A Mitros

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