PMID: 16502481Feb 28, 2006Paper

Genetic markers for differentiating aspirin-hypersensitivity

Yonsei Medical Journal
Seung-Hyun Kim, Hae-Sim Park

Abstract

Aspirin-induced asthma (AIA) and aspirin-induced urticaria/ angioedema (AIU) are two major aspirin-related allergies. We summarize recent findings related to their molecular genetic mechanisms in order to identify genetic susceptibility markers for differentiating AIU and AIA. The overproduction of cysteinyl leukotriene has been suggested as a mechanism in both AIU and AIA. Increased expression of CYSLTR1 with CYLSTR1 and CYSLTR2 polymorphisms are new findings in AIA, while the ALOX5 promoter polymorphism has been noted in AIU. An HLA study suggested that DPB1*0301 is a strong genetic marker for AIA, and that HLA DRB1*1302 and DQB1*0609 are markers for AIU susceptibility. Several single nucleotide polymorphisms (SNPs) in the promoters of EP2, TBX21, COX-2, Fc epsilon RIbeta, and TBXA2R were associated with AIA, while an Fc epsilon RIalpha promoter polymorphism was associated with AIU. The functional studies of the key genes involved in AIA and AIU are summarized. The identification and functional study of genetic markers for AIA and AIU susceptibility would further elucidate the pathogenic mechanisms and facilitate the development of early diagnostic markers to establish therapeutic targets.

References

May 1, 1991·The American Review of Respiratory Disease·P E ChristieT H Lee
Jan 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H S Park
May 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J W DekkerA Szczeklik
Jun 15, 2000·The European Respiratory Journal·E NizankowskaA Szczeklik
Dec 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M PierzchalskaA Szczeklik
Jan 5, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M J Torres-GalvánJ Quiralte
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·Sven-Erik DahlénAndrew Szczeklik
Jun 14, 2002·The Journal of Allergy and Clinical Immunology·Yukio KawagishiKazuo Akiyama
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Adam AntczakPeter J Barnes
Feb 7, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S TornhamreJ A Lindgren
Mar 26, 2003·Clinical and Experimental Dermatology·C E H Grattan
Apr 2, 2003·Clinical Reviews in Allergy & Immunology·Mario Sánchez-BorgesFernan Caballero-Fonseca
May 14, 2003·The Journal of Allergy and Clinical Immunology·Andrew Szczeklik, Donald D Stevenson
Dec 19, 2003·Current Allergy and Asthma Reports·Ronald A Simon
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Jeong Hee ChoiHae-Sim Park
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Lucyna MastalerzAndrew Szczeklik
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·Wojciech SzczeklikAndrew Szczeklik
Mar 24, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S-H KimH-S Park
Apr 5, 2005·Human Genetics·Mitsuteru AkahoshiTaro Shirakawa
May 19, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S-H KimH-D Shin
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·H S Park

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Citations

Jul 27, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Claudia JenneckNatalija Novak
Nov 7, 2007·The Pediatric Infectious Disease Journal·Roberto P SantosTheresa Barton
Aug 2, 2012·Allergy & Rhinology·Mario Sánchez-BorgesFernan Caballero-Fonseca
May 4, 2013·Immunology and Allergy Clinics of North America·Mario Sánchez-BorgesArnaldo Capriles-Hulett
Jul 9, 2010·The Medical Clinics of North America·Mario Sánchez-Borges
Mar 3, 2009·Journal of Clinical Pharmacy and Therapeutics·J H ChoiH S Park
Nov 13, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N S PalikheH-S Park
Jul 15, 2015·Journal of Zhejiang University. Science. B·Jing LiTing-hong Lv
Jan 10, 2014·Allergy, Asthma & Immunology Research·Purevsuren LosolHae-Sim Park
Oct 8, 2016·Immunology and Allergy Clinics of North America·Amber Dahlin, Scott T Weiss
Jul 28, 2017·Journal of Clinical Pharmacology·Luciana Mabel Ferreira VasconcelosAparecida Tiemi Nagao-Dias
Jan 5, 2010·Pharmaceuticals·Mario Sánchez-BorgesLuis González-Aveledo
Apr 4, 2020·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Tobial McHughDoron D Sommer
Dec 24, 2019·Frontiers in Pediatrics·Hui ZhangAijie Li
Sep 26, 2019·Allergy, Asthma & Immunology Research·Jong Uk LeeChoon Sik Park
Mar 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nan BiLuhua Wang

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