PMID: 25731625Mar 4, 2015Paper

Genetic markers in biological fluids for aging-related major neurocognitive disorder

Current Alzheimer Research
S A Castro-ChaviraR A Prado-Alcala

Abstract

Aging-related major neurocognitive disorder (NCD), formerly named dementia, comprises of the different acquired diseases whose primary deficit is impairment in cognitive functions such as complex attention, executive function, learning and memory, language, perceptual/motor skills, and social cognition, and that are related to specific brain regions and/or networks. According to its etiology, the most common subtypes of major NCDs are due to Alzheimer' s disease (AD), vascular disease (VaD), Lewy body disease (LBD), and frontotemporal lobar degeneration (FTLD). These pathologies are frequently present in mixed forms, i.e., AD plus VaD or AD plus LBD, thus diagnosed as due to multiple etiologies. In this paper, the definitions, criteria, pathologies, subtypes and genetic markers for the most common age-related major NCD subtypes are summarized. The current diagnostic criteria consider cognitive decline leading to major NCD or dementia as a progressive degenerative process with an underlying neuropathology that begins before the manifestation of symptoms. Biomarkers associated with this asymptomatic phase are being developed as accurate risk factor and biomarker assessments are fundamental to provide timely treatment since no tre...Continue Reading

Citations

Dec 8, 2016·Behavioural Pharmacology·Alfredo Meneses
Mar 2, 2018·Current Medicinal Chemistry·Tommaso BonfiglioAnna Pittaluga
Mar 24, 2020·Environmental Science and Pollution Research International·Md Ataur RahmanHyewhon Rhim
May 31, 2018·Molecular Medicine Reports·Mubashir HassanAhmed A Moustafa

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