Genetic markers in methotrexate treatments

The Pharmacogenomics Journal
Andrea Giletti, Patricia Esperon

Abstract

Methotrexate (MTX), a structural analog of folic acid, is widely employed in the treatment of different cancers and autoimmune diseases. Despite the successful results observed, the main disadvantage lies in interpatient variability in the pharmacokinetic and pharmacodynamic parameters. In particular, adverse events and toxicities induced by MTX are a matter of concern and can be the cause of dose reduction or treatment discontinuation. Among the different approaches to reduce MTX therapeutic limitations, pharmacogenomics contributes by considering the effect of inherited genetic differences on those parameters. This review provides an update on MTX pharmacogenomics. It reports the contribution of main gene polymorphisms involved in the influx, efflux, cellular effect, and elimination on MTX toxicity and efficacy, on all the diseases treated with this drug. From the analysis of the data presented in this review, we concluded that only gene polymorphisms MTHFR rs1801133, SLC19A1 rs1051266, and TYMS rs34743033 could influence clinical decision-making.

References

Nov 28, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P ChiusoloS Sica
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kim RobienCornelia M Ulrich
Oct 13, 2004·The Oncologist·Maitreyee HazarikaRichard Pazdur
Jun 3, 2005·Clinical Colorectal Cancer·Bruce J Dolnick
May 17, 2006·The Journal of Pharmacology and Experimental Therapeutics·Ilaria BadagnaniKathleen M Giacomini
Feb 1, 2007·Blood·Shinji KishiMary V Relling
Apr 6, 2007·The Journal of Investigative Dermatology·Emanuela CampalaniCatherine H Smith
Dec 22, 2007·Blood·Stéphanie DulucqMaja Krajinovic
Feb 12, 2009·The Journal of Rheumatology·Mark C Fisher, Bruce N Cronstein
Oct 24, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Cheryl A Thompson
Oct 29, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fidaa Al-ShakfaMaja Krajinovic
Nov 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa R TreviñoMary V Relling
Apr 25, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lin YangLuhang Xu
Jan 8, 2013·Cancer Chemotherapy and Pharmacology·Samira Sadat AbolmaaliRassoul Dinarvand

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Citations

Feb 14, 2019·Journal of Clinical Medicine·Rabia Mukhtar RanaKeun Woo Lee
Jul 25, 2021·The Pharmacogenomics Journal·Anna WajdaAgnieszka Paradowska-Gorycka

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