Genetic Markers of ADHD-Related Variations in Intracranial Volume

The American Journal of Psychiatry
Marieke KleinBarbara Franke

Abstract

Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) and volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, and putamen are smaller in people with ADHD compared with healthy individuals. The authors investigated the overlap between common genetic variation associated with ADHD risk and these brain volume measures to identify underlying biological processes contributing to the disorder. The authors combined genome-wide association results from the largest available studies of ADHD (N=55,374) and brain volumes (N=11,221-24,704), using a set of complementary methods to investigate overlap at the level of global common variant genetic architecture and at the single variant level. Analyses revealed a significant negative genetic correlation between ADHD and ICV (rg=-0.22). Meta-analysis of single variants revealed two significant loci of interest associated with both ADHD risk and ICV; four additional loci were identified for ADHD and volumes of the amygdala, caudate nucleus, and putamen. Exploratory gene-based and gene-set analyses in the ADHD-ICV meta-analytic data showed association with variati...Continue Reading

Citations

Apr 25, 2019·The American Journal of Psychiatry·Martine HoogmanBarbara Franke
Jun 23, 2019·Molecular Psychiatry·Edward D BarkerUNKNOWN IMAGEN Consortium
Dec 23, 2020·Nature Human Behaviour·Frank R WendtRenato Polimanti
Nov 14, 2020·Translational Psychiatry·Alexander NeumannHenning Tiemeier
Apr 6, 2021·Psychological Medicine·Isabell BrikellJoanna Martin
May 8, 2021·Journal of Clinical and Experimental Neuropsychology·Tina ThomasElena L Grigorenko
Aug 10, 2021·Annual Review of Developmental Psychology·Joel T NiggSarah L Karalunas
Sep 8, 2021·Frontiers in Genetics·Mark Z KosCharles Ákos Szabó

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Software Mentioned

Multimarker Analysis of GenoMic Annotation ( MAGMA )
SECA
CHARGE
PLINK
ENIGMA
R scripts
MAGMA

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