Genetic Mechanisms of Asthma and the Implications for Drug Repositioning

Genes
Yue Huo, Hong-Yu Zhang

Abstract

Asthma is a chronic disease that is caused by airway inflammation. The main features of asthma are airway hyperresponsiveness (AHR) and reversible airway obstruction. The disease is mainly managed using drug therapy. The current asthma drug treatments are divided into two categories, namely, anti-inflammatory drugs and bronchodilators. However, disease control in asthma patients is not very efficient because the pathogenesis of asthma is complicated, inducing factors that are varied, such as the differences between individual patients. In this paper, we delineate the genetic mechanisms of asthma, and present asthma-susceptible genes and genetic pharmacology in an attempt to find a diagnosis, early prevention, and treatment methods for asthma. Finally, we reposition some clinical drugs for asthma therapy, based on asthma genetics.

References

Jul 1, 1996·British Journal of Clinical Pharmacology·P J Barnes
May 30, 2001·European Journal of Human Genetics : EJHG·M F MoffattW O Cookson
Sep 7, 2001·Nature Genetics·A J WalleyW O Cookson
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Nobuyuki HizawaMasaharu Nishimura
Nov 28, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·William E BergerUNKNOWN Desloratadine Study Group
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Ross LazarusScott T Weiss
Jul 30, 2004·American Journal of Respiratory and Critical Care Medicine·Benjamin A RabyScott T Weiss
Feb 16, 2005·American Journal of Respiratory and Critical Care Medicine·Erik MelénUNKNOWN PARSIFAL Genetics Study Group
Feb 19, 2005·Human Molecular Genetics·Pirro HysiWilliam O C Cookson
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·Lauren A WeissCarole Ober
Jun 25, 2005·American Journal of Respiratory and Critical Care Medicine·Adrienne G RandolphScott T Weiss
Oct 12, 2005·Journal of Human Genetics·Hyun Sub CheongHyoung Doo Shin
Oct 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T F LeungG W K Wong
Nov 19, 2005·American Journal of Respiratory and Critical Care Medicine·John J LimaKathleen Barnes
Jan 6, 2006·Genes and Immunity·C Ober, S Hoffjan
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Benjamin A RabyScott T Weiss
Feb 17, 2006·The New England Journal of Medicine·Mike A BerryIan D Pavord
Jun 15, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Jian ZhangEmiko Noguchi
Jul 15, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N HizawaM Nishimura
Jan 4, 2007·American Journal of Respiratory and Critical Care Medicine·Christopher J Edwards, Riccardo Polosa
Mar 17, 2007·American Journal of Respiratory and Critical Care Medicine·Philippe BéginCatherine Laprise
Nov 6, 2007·The Journal of Allergy and Clinical Immunology·Kelan G TantisiraScott T Weiss
Nov 27, 2007·The Journal of Allergy and Clinical Immunology·Christopher BrightlingYassine Amrani
Feb 28, 2008·Nature Reviews. Immunology·Donata Vercelli
Mar 26, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Gonneke WillemsenDorret I Boomsma
May 1, 2008·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Manoj R Warrier, Gurjit K Khurana Hershey
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephen T Holgate
Jul 17, 2008·Comparative and Functional Genomics·Maxim B FreidinValery P Puzyrev
Aug 7, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Larry Borish, Jeffrey A Culp
Dec 17, 2008·Current Opinion in Pulmonary Medicine·John J LimaScott T Weiss
Dec 20, 2008·American Journal of Respiratory and Critical Care Medicine·Lidwien A M SmitUNKNOWN Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA) Cooperative
Jan 10, 2009·The Journal of Allergy and Clinical Immunology·Erika von Mutius
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jun 2, 2009·Current Opinion in Genetics & Development·Scott T WeissAngela Rogers
Aug 13, 2009·Respiration; International Review of Thoracic Diseases·Jinming GaoYouming Zhang
Sep 10, 2009·Clinical and Experimental Immunology·D Desai, C Brightling
Nov 7, 2009·American Journal of Respiratory and Critical Care Medicine·Wendy C MooreUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program

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Citations

Jul 3, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jelena DinićIvanka Tsakovska

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Methods Mentioned

BETA
genotyping

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