Genetic mechanisms of knee osteoarthritis: a population based case-control study

Annals of the Rheumatic Diseases
G JonesF M Cicuttini

Abstract

To compare subjects who had at least one parent with a total knee replacement for severe primary knee osteoarthritis with age and sex matched controls who had no family history of knee osteoarthritis Population based case-control study of 188 matched pairs (mean age 45 years, range 26 to 60). Articular cartilage volume and bone size were determined at the patella and at the medial tibial and lateral tibial compartments by processing images acquired using T1 weighted, fat saturated magnetic resonance imaging. Radiographic osteoarthritis (ROA) was assessed from a standing semiflexed radiograph scored for joint space narrowing and osteophytosis. Knee pain was assessed by questionnaire. Height, weight, body mass index (BMI), lower limb muscle strength, and endurance fitness were measured by standard protocols. Compared with the controls, index offspring had higher BMI (27.8 v 26.0 kg/m(2), p = 0.02), weaker lower limb muscles (127 v 135 kg, p = 0.006), more knee pain (47% v 22%, p<0.001), and greater medial tibial bone area (17.6 v 17.1 cm(2), p = 0.01). With the exception of BMI, these differences persisted in multivariate analysis. There was a non-significant trend to higher cartilage volume at tibial sites and increased ROA in t...Continue Reading

References

Sep 16, 1977·European Journal of Applied Physiology and Occupational Physiology·R T WithersR G Crouch
Oct 1, 1992·Annals of the Rheumatic Diseases·T D Spector, D J Hart
Jan 1, 1995·Journal of Orthopaedic Trauma·S E Honkonen
Apr 13, 1996·BMJ : British Medical Journal·T D SpectorD Hart
Jun 3, 1998·Current Opinion in Rheumatology·D B Burr
Feb 27, 2001·Current Opinion in Rheumatology·J Loughlin
May 22, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D CoggonC Cooper
Aug 25, 2001·Osteoarthritis and Cartilage·L LachanceM Crutchfield
Sep 15, 2001·Annals of the Rheumatic Diseases·F M CicuttiniS L Stuckey
Aug 14, 2002·Rheumatology·J Y Reginster
Jul 2, 2003·Rheumatology·David J HunterPhilip N Sambrook

❮ Previous
Next ❯

Citations

Mar 31, 2006·Clinical Rheumatology·Guangju ZhaiGraeme Jones
Apr 13, 2005·Trends in Molecular Medicine·Chris A PeachJohn Loughlin
Mar 17, 2005·Annals of the Rheumatic Diseases·C DingG Jones
Dec 17, 2005·Arthritis Research & Therapy·Changhai DingGraeme Jones
Jan 6, 2016·BMC Musculoskeletal Disorders·Hussain Ijaz KhanGraeme Jones
Dec 9, 2008·The Medical Clinics of North America·Ana M Valdes, Timothy D Spector
Aug 9, 2008·Rheumatic Diseases Clinics of North America·Ana M Valdes, Timothy D Spector
Apr 1, 2005·Obesity Research·Changhai DingGraeme Jones
Sep 14, 2018·BMC Musculoskeletal Disorders·Barton L WiseNancy E Lane

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.