Genetic model of transformation and neoplastic progression in laryngeal epithelium

Head & Neck
César Alvarez MarcosJosé L Llorente

Abstract

The aim of this study was to analyze genetic alterations in the transformation-progression model of laryngeal tumors. Copy number changes of 37 genes were analyzed by multiple ligation-dependent probe amplification (MLPA) in 94 tissue samples. In the smoker normal mucosa group TP53 loss was predominant, whereas in the precursor lesions CDKN2A loss and CDKN2D gain were most frequent. Precursor lesions with progression presented CTNNB1 loss. In the carcinoma group the most common changes were CDKN2A, MLH1, CTNNB1, and CASP6 losses and RECQL4, CCND1, and EMS1 gains. Positive lymph node primary tumors were related to TP53, IL1A, and RB1 losses and STK11 gain. The lymph node metastases differed from their corresponding primary tumor in LMNA, RECQL4, and IGF1R losses, and N33 and CDKN2D gains. Genetic changes and new key genes were found to be associated with specific steps. We included new steps, not presented in the classic models: normal mucosa tobacco exposed, positive lymph node primary tumor, and corresponding lymph node metastases.

References

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Citations

Apr 9, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Fernando LópezJosé L Llorente
Mar 11, 2016·Current Opinion in Otolaryngology & Head and Neck Surgery·Sumita TrivediRobert L Ferris
Sep 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Rauf Oguzhan KumAdnan Unal
Nov 10, 2012·Acta Oto-laryngologica·César Álvarez-MarcosJosé L Llorente
Jul 6, 2016·Pathology Oncology Research : POR·Fernando LópezCésar Álvarez-Marcos
Sep 1, 2017·Current Opinion in Otolaryngology & Head and Neck Surgery·Noah P Parker
Sep 30, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ping WanKenneth W Altman
Dec 20, 2013·Cellular Oncology (Dordrecht)·Ilda Patrícia RibeiroIsabel Marques Carreira
Apr 28, 2018·Scientific Reports·Lorea ManterolaCharles Henderson Lawrie
Feb 1, 2021·Journal of Voice : Official Journal of the Voice Foundation·Abdul-Latif HamdanElie Khalifee

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