Genetic models with reduced penetrance related to the Y chromosome

Biometrics
R W Darling, T Holt

Abstract

Classical statistical genetics models of a quantitative trait depending on an autosomal gene indicate that father-to-daughter and mother-to-son correlations should be the same. If phenotypes are not sex-dependent, father-to-son and mother-to-daughter correlations also share this common value. On the other hand, if the gene is sex-linked, then the father-to-son correlation is zero. Such models do not explain genetic variation in pulmonary artery pressure (PAP) of cattle--important because cattle with high PAP are known to develop brisket disease, pulmonary heart disease, and congestive heart failure when taken to high altitudes. Data on 966 calves at a ranch in Colorado showed positive correlation (0.2) between sire PAP and male calf PAP but slightly negative correlation (-0.01) between sire PAP and female calf PAP; the dam-to-male calf and dam-to-female calf correlations are both about 0.1. The model presented here postulates an autosomal gene with reduced penetrance (i.e., the trait may remain at a normal level even when the genotype suggests abnormality) and that, in males, the rate of penetrance is related to an abnormality in the Y chromosome and is therefore passed on from father to son. Then under plausible selective bree...Continue Reading

References

Nov 1, 1974·Cardiovascular Research·E K WeirR F Grover
May 1, 1967·Annals of Human Genetics·C R Leach, O Mayo
Jun 1, 1949·Annals of Eugenics·J B S HALDANE
Feb 1, 1990·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·O MayoC R Leach

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Citations

Oct 9, 2007·The Veterinary Clinics of North America. Food Animal Practice·Timothy N Holt, Robert J Callan
Jun 1, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D ElyA Milsted
Dec 25, 2007·Journal of Animal Science·K L ShirleyD J Garrick

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