Genetic modification of iron metabolism in mice affects the gut microbiota

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Keren Buhnik-RosenblauEsther G Meyron-Holtz

Abstract

The composition of the gut microbiota is affected by environmental factors as well as host genetics. Iron is one of the important elements essential for bacterial growth, thus we hypothesized that changes in host iron homeostasis, may affect the luminal iron content of the gut and thereby the composition of intestinal bacteria. The iron regulatory protein 2 (Irp2) and one of the genes mutated in hereditary hemochromatosis Hfe , are both proteins involved in the regulation of systemic iron homeostasis. To test our hypothesis, fecal metal content and a selected spectrum of the fecal microbiota were analyzed from Hfe-/-, Irp2-/- and their wild type control mice. Elevated levels of iron as well as other minerals in feces of Irp2-/- mice compared to wild type and Hfe-/- mice were observed. Interestingly significant variation in the general fecal-bacterial population-patterns was observed between Irp2-/- and Hfe-/- mice. Furthermore the relative abundance of five species, mainly lactic acid bacteria, was significantly different among the mouse lines. Lactobacillus (L.) murinus and L. intestinalis were highly abundant in Irp2-/- mice, Enterococcus faecium species cluster and a species most similar to Olsenella were highly abundant in ...Continue Reading

References

Jan 1, 1993·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G BenoniI Caramazza
Jun 26, 1998·Current Microbiology·M Imbert, R Blondeau
Nov 7, 2002·European Journal of Nutrition·Michael Blaut
Jun 28, 2003·FEMS Microbiology Reviews·Simon C AndrewsFrancisco Rodríguez-Quiñones
Nov 18, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Thomas HerrmannWolfgang Stremmel
Apr 16, 2005·Science·Paul B EckburgDavid A Relman
Jun 3, 2006·Science·Steven R GillKaren E Nelson
Jul 20, 2006·Nature Chemical Biology·Tracey A Rouault
Aug 29, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·S F DrakeD Trinder
Jan 12, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Elizabeth E WyckoffShelley M Payne
Feb 22, 2007·The Journal of Nutrition·Maya Pineiro, Catherine Stanton
Nov 29, 2007·Current Opinion in Gastroenterology·Daniel N Frank, Norman R Pace
May 24, 2008·Science·Ruth E LeyJeffrey I Gordon
Aug 30, 2008·PloS One·Zaruhi A KhachatryanRustam I Aminov
Dec 31, 2008·World Journal of Gastroenterology : WJG·Volker Mai, Peter V Draganov
Jul 15, 2009·Experimental Biology and Medicine·Andrew S BarbasWilliam Parker
Nov 7, 2009·Science·Elizabeth K CostelloRob Knight
Mar 6, 2010·Science·Matam Vijay-KumarAndrew T Gewirtz
Mar 23, 2010·Cell·Wendy S GarrettLaurie H Glimcher
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peter J TurnbaughJeffrey I Gordon
Apr 7, 2010·Science Translational Medicine·Peter J TurnbaughJeffrey I Gordon
Jun 18, 2010·The Cochrane Database of Systematic Reviews·Stefan D HolubarDarrell S Pardi
Sep 17, 2010·Expert Review of Molecular Diagnostics·Pierre BrissotAnne-Marie Jouanolle
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrew K BensonDaniel Pomp
Oct 27, 2010·International Journal of Inflammation·R Steven EsworthyFong-Fong Chu
Dec 15, 2010·Current Opinion in Pediatrics·Clara Camaschella, Erika Poggiali
Feb 1, 2011·Current Opinion in Chemical Biology·Volkmar Braun, Klaus Hantke
Mar 17, 2011·Nature Reviews. Microbiology·Aymé SporRuth Ley

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Citations

Jul 3, 2013·Nutrients·Xiang Xue, Yatrik M Shah
Jan 15, 2015·Expert Review of Respiratory Medicine·Rajneesh Malhotra, Henric Olsson
Apr 22, 2015·Journal of Clinical Pathology·Lize F D van VulpenRoger E G Schutgens
Sep 11, 2014·FEMS Microbiology Reviews·Guus A M KortmanHarold Tjalsma
Sep 1, 2016·Wiener medizinische Wochenschrift·Oliver Ng
Nov 13, 2018·Acta Microbiologica Et Immunologica Hungarica·Audrone MulevicieneAugustina Jankauskiene
Sep 9, 2017·Critical Reviews in Food Science and Nutrition·José Manuel Fernández RealMelania Manco
Sep 16, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean-Christophe DescheminGaël Nicolas
Sep 21, 2018·Genetics and Molecular Biology·Karina ColonettiIda Vanessa Doederlein Schwartz
May 15, 2019·Nutrients·Chang-Kyu Oh, Yuseok Moon
Apr 13, 2018·Antioxidants·James FrielChenxi Cai
Oct 12, 2018·Pharmaceuticals·Bahtiyar Yilmaz, Hai Li
Sep 22, 2020·The Biochemical Journal·Sathish SivaprakasamVadivel Ganapathy
Oct 25, 2020·International Journal of Molecular Sciences·Carine FillebeenKostas Pantopoulos

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