Genetic modifiers in mice: the example of the fragile X mouse model

Cytogenetic and Genome Research
V Errijgers, R F Kooy

Abstract

Modifiers play an important role in most, if not all human diseases, and mouse models. For some disease models, such as the cystic fibrosis knockout mouse model, the effect of genetic factors other than the causative mutation has been well established and a modifier gene has been mapped. For other mouse models, including those of the fragile X syndrome, a common form of inherited mental retardation, controversies between test results obtained in different laboratories have been well recognized. Yet, the possibility that modifiers could at least explain part of the discrepancies is only scarcely mentioned. In this review we compare the test results obtained in different laboratories and provide evidence that modifiers may affect disease severity in the fragile X knockout mouse.

Citations

Oct 9, 2008·Genetics Research·Vanessa ErrijgersR Frank Kooy
Apr 7, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Przemko TylzanowskiFrank P Luyten
Nov 5, 2013·Neuroscience and Biobehavioral Reviews·Celine E F de EschRob Willemsen
May 15, 2020·Molecular Psychiatry·Shannon J MooreVictor A Cazares
Sep 19, 2020·Journal of Developmental and Behavioral Pediatrics : JDBP·Wilmar SaldarriagaRandi J Hagerman

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