Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial.

The Pharmacogenomics Journal
K L EllisI Peter

Abstract

Modifiers of response to glucose, insulin and potassium (GIK) infusion may affect clinical outcomes in acute coronary syndromes (ACS). In an Immediate Myocardial Metabolic Enhancement During Initial Assessment And Treatment In Emergency Care (IMMEDIATE) trial's sub-study (n = 318), we explored effects of 132,634 genetic variants on plasma glucose and potassium response to 12-h GIK infusion. Associations between metabolite-associated variants and infarct size (n = 84) were assessed. The 'G' allele of rs12641551, near ACSL1, as well as the 'A' allele of XPO4 rs2585897 were associated with a differential glucose response (P for 2 degrees of freedom test, P2df ⩽ 4.75 × 10(-7)) and infarct size with GIK (P2df < 0.05). Variants within or near TAS1R3, LCA5, DNAH5, PTPRG, MAGI1, PTCSC3, STRADA, AKAP12, ARFGEF2, ADCYAP1, SETX, NDRG4 and ABCB11 modified glucose response, and near CSF1/AHCYL1 potassium response (P2df ⩽ 4.26 × 10(-7)), but not outcomes. Gene variants may modify glucose and potassium response to GIK infusion, contributing to cardiovascular outcomes in ACS.

References

Aug 16, 2000·The EMBO Journal·G LipowskyD Görlich
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·W A ChutkowC F Burant
Nov 26, 2002·Journal of the American College of Cardiology·Nazneem N WahabUNKNOWN ICONS Investigators
Feb 5, 2003·The American Journal of Cardiology·Harry P SelkerW Douglas Weaver
Jul 25, 2007·Clinical and Experimental Pharmacology & Physiology·Ben-Zhi CaiBao-Feng Yang
Mar 24, 2009·Nature Genetics·Christopher Newton-ChehBruno H Ch Stricker
Mar 24, 2009·Nature Genetics·Arne PfeuferAravinda Chakravarti
Dec 25, 2009·Circulation. Cardiovascular Genetics·Fabio MarroniUNKNOWN EUROSPAN Consortium
May 27, 2010·The Journal of Clinical Investigation·Bernhard MaierRaghavendra G Mirmira
Dec 25, 2010·Journal of Applied Physiology·Claude BouchardTuomo Rankinen
Jan 20, 2011·Molecular and Cellular Biology·Jessica M EllisRosalind A Coleman
Aug 9, 2011·Journal of Cardiovascular Pharmacology and Therapeutics·Raymond J Gibbons
Jun 5, 2012·Circulation. Cardiovascular Genetics·Catherine O JohnsonThomas D Rea
Oct 22, 2013·Metabolism: Clinical and Experimental·Edgars LiepinshMaija Dambrova

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