Genetic mouse models of schizophrenia: from hypothesis-based to susceptibility gene-based models

Biological Psychiatry
Jingshan ChenDaniel R Weinberger

Abstract

Translation of human genetic mutations into genetic mouse models is an important strategy to study the pathogenesis of schizophrenia, identify potential drug targets, and test new drugs for new antipsychotic treatments. Although it is impossible to recapitulate the full spectrum of schizophrenia symptoms in animal models, hypothesis-driven genetic mouse models have been successful in reproducing several schizophrenia-like behaviors and uncovering the roles of specific genes in dopamine and glutamine neurotransmission systems in mediating schizophrenia-like behaviors. Recent discoveries of susceptibility genes for schizophrenia and recognition of cognitive dysfunction as a core feature of schizophrenia and a phenotype of susceptibility for schizophrenia offer opportunities to develop newer genetic mouse models based on susceptibility. This new generation of genetic mouse models could shed light on the etiology of schizophrenia and lead us to new hypotheses, novel diagnostic tools, and more effective therapy.

References

Jan 1, 1974·Journal of Psychiatric Research·A Randrup, I Munkvad
Aug 1, 1972·Archives of General Psychiatry·S H Snyder
Aug 1, 1995·Schizophrenia Research·D R Weinberger, B K Lipska
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·T OhshimaA B Kulkarni
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R FreedmanW Byerley
Jan 1, 1997·Molecular Psychiatry·A M VicenteJ L Kennedy
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A GogosM Karayiorgou
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·F ImpagnatielloE Costa
Apr 17, 1999·American Journal of Medical Genetics·H KojimaK Abe
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·W E LyonsL Tessarollo
Jan 19, 2000·Molecular Medicine Today·R R Gainetdinov, M G Caron
Mar 16, 2000·The EMBO Journal·S G KernieL F Parada
Mar 17, 2000·Brain Research. Brain Research Reviews·J H Meador-Woodruff, D J Healy
Mar 17, 2000·Brain Research. Brain Research Reviews·A A Fienberg, P Greengard
May 18, 2000·Human Molecular Genetics·J K MillarD J Porteous
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·A Abi-DarghamM Laruelle
Aug 16, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B K Lipska, D R Weinberger
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·X ZhuangR Hen
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·D J GerberS Tonegawa
Jan 12, 2002·Current Opinion in Pharmacology·Erminio CostaAlessandro Guidotti
Feb 19, 2002·The European Journal of Neuroscience·Marko HuotariPekka T Männistö
Apr 2, 2002·The American Journal of Psychiatry·Kenneth S Kendler
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jenn-Yah YuDavid L Turner
May 25, 2002·Human Molecular Genetics·Kodavali V ChowdariVishwajit L Nimgaonkar
Aug 2, 2002·Archives of General Psychiatry·Katherine A AlbertPaul Greengard
Dec 12, 2002·Molecular Psychiatry·M A GeyerR Paylor
Dec 13, 2002·American Journal of Human Genetics·Hreinn StefanssonDavid St Clair
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Niklas LindgrenGilberto Fisone
May 15, 2003·Journal of Medical Genetics·D KamnasaranD W Cox
Jun 5, 2003·Lancet·Maria Karayiorgou, Joseph A Gogos
Jul 2, 2003·The American Journal of Psychiatry·Michael F EganBai Lu
Jul 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tsuyoshi MiyakawaSusumu Tonegawa

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Citations

May 20, 2009·Neuropsychology Review·James M GoldJames A Waltz
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael E CahillPeter Penzes
Nov 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lisha ShaoYi Zhong
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Amanda J LawDaniel R Weinberger
Apr 15, 2008·Schizophrenia Bulletin·Urs MeyerBenjamin K Yee
May 2, 2008·Schizophrenia Bulletin·S Kristian HillJohn A Sweeney
Nov 26, 2009·Schizophrenia Bulletin·Colm M P O'TuathaighJohn L Waddington
Oct 16, 2009·Neuroreport·Inga H DeakinDavid M Bannerman
Apr 8, 2010·Science Translational Medicine·Vivian W ChowPhilip C Wong
Jan 1, 2008·Cytogenetic and Genome Research·H M Lachman
May 10, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yu TaniguchiAtsushi Kamiya
Jul 19, 2006·Diagnostic Pathology·Shaheen Emmanuel Lakhan
Sep 2, 2011·Biological & Pharmaceutical Bulletin·Lingling LuToshitaka Nabeshima
Jul 17, 2010·PloS One·Xiaowei ZhangRussell E Jacobs
Jan 21, 2011·Journal of Psychiatry & Neuroscience : JPN·Noah L LazarDonald P Cain
Feb 22, 2012·Journal of Psychiatry & Neuroscience : JPN·Patricia Boksa
Jul 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ying-Jiun J ChenLorna W Role
Apr 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·A V SavonenkoP C Wong
Aug 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Takatoshi HikidaAkira Sawa
Oct 30, 2015·Progress in Neurobiology·Yavuz AyhanMikhail V Pletnikov
Aug 5, 2009·Neuroscience and Biobehavioral Reviews·Dragos IntaPeter Gass
Jan 15, 2008·Biological Psychiatry·Takatoshi HikidaAkira Sawa
Mar 22, 2008·Brain Research Bulletin·German TorresJudith M Horowitz
Nov 6, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Colm M P O'TuathaighJohn L Waddington
Aug 28, 2007·The Psychiatric Clinics of North America·John L WaddingtonMichael Gill
Jul 30, 2011·Biological Psychiatry·Michael A McDannaldGeoffrey Schoenbaum
Apr 3, 2016·Behavioural Brain Research·Gyongyi HorvathAttila Nagy
Feb 2, 2013·Neurobiology of Disease·Roman Willi, Martin E Schwab
Oct 25, 2012·Neuroscience and Biobehavioral Reviews·Eva DrewsAndreas Zimmer
Oct 4, 2006·Neuron·Christopher A RossJoseph T Coyle
Oct 4, 2006·Neuron·P Alexander Arguello, Joseph A Gogos

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