Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing

International Journal of Clinical Oncology
Shinichiro YasukawaAkihiro Homma

Abstract

The mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated. To clarify the genes responsible for the malignant transformation, we analyzed 10 cases of IP, 8 of IP with dysplasia, and 11 of squamous cell carcinoma (SCC) by targeted amplicon sequencing. The number of mutant genes increased in the order of IP < dysplasia < SCC. Significant differences were observed in the mutation rates of three genes (KRAS, APC and STK11) in particular. TP53 was altered frequently in each group and might be involved in malignant transformation based on to the site of the mutation. A comparison of the genetic variants by region of IP tissue among patients with IP alone, and those with dysplasia or SCC revealed significant differences in the mutation rate of the KRAS gene. Identification of genetic mutations in KRAS is effective for predicting the malignant transformation of IP.

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Citations

Jul 30, 2020·Current Oncology Reports·Matt LechnerValerie J Lund
May 2, 2020·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Cai LongAndrew Thamboo
Oct 14, 2020·Virchows Archiv : an International Journal of Pathology·Sarah ZonnurBjörn Schneider
Dec 19, 2020·Current Opinion in Otolaryngology & Head and Neck Surgery·Charles C L Tong, James N Palmer
Jul 29, 2021·Acta Oncologica·Sannia SjöstedtKasper Aanaes

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