Abstract
The mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated. To clarify the genes responsible for the malignant transformation, we analyzed 10 cases of IP, 8 of IP with dysplasia, and 11 of squamous cell carcinoma (SCC) by targeted amplicon sequencing. The number of mutant genes increased in the order of IP < dysplasia < SCC. Significant differences were observed in the mutation rates of three genes (KRAS, APC and STK11) in particular. TP53 was altered frequently in each group and might be involved in malignant transformation based on to the site of the mutation. A comparison of the genetic variants by region of IP tissue among patients with IP alone, and those with dysplasia or SCC revealed significant differences in the mutation rate of the KRAS gene. Identification of genetic mutations in KRAS is effective for predicting the malignant transformation of IP.
References
Jan 1, 1995·The Laryngoscope·C BuchwaldM Tos
Sep 1, 1996·Acta Oto-laryngologica·T Deitmer, C Wiener
Apr 10, 1999·Clinical Otolaryngology and Allied Sciences·R J Sanderson, P Knegt
Mar 10, 2001·Advances in Anatomic Pathology·J G Batsakis, P Suarez
Jul 18, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R J SchlosserC W Gross
Sep 16, 2003·The Laryngoscope·William LawsonHugh F Biller
Jul 3, 2010·Head and Neck Pathology·Hope H WuBeverly Y Wang
Jun 18, 2011·Nature Reviews. Genetics·John W DaveyMark L Blaxter
Apr 3, 2012·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Semih OncelErcan Pinar
Apr 27, 2012·American Journal of Otolaryngology·Gun-Ho LeeKi-Sang Rha
Sep 17, 2013·International Forum of Allergy & Rhinology·Giant C LinMark A Zacharek
Jan 10, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M ReC Rubini
Jul 12, 2014·BioMed Research International·Yung-An TsouCalvin Yu-Chian Chen
Dec 17, 2014·Current Drug Targets·Simona CocoFrancesco Grossi
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network
May 2, 2015·Cancer Research·Aaron M UdagerNoah A Brown
Aug 6, 2015·Infectious Agents and Cancer·Yukashi YamashitaMikio Suzuki
Apr 18, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ren-Wu ZhaoRu-Xin Zhang
May 29, 2016·The Journal of Pathology·Aaron M UdagerNoah A Brown
Citations
Nov 20, 2019·The American Journal of Surgical Pathology·Mitra MehradJames S Lewis
Mar 28, 2019·Histopathology·Huan WangXicai Sun
Jul 30, 2020·Current Oncology Reports·Matt LechnerValerie J Lund
May 2, 2020·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Cai LongAndrew Thamboo
May 2, 2019·Head & Neck·Diana BellEhab Y Hanna
Oct 14, 2020·Virchows Archiv : an International Journal of Pathology·Sarah ZonnurBjörn Schneider
Dec 19, 2020·Current Opinion in Otolaryngology & Head and Neck Surgery·Charles C L Tong, James N Palmer
Apr 16, 2021·Scientific Reports·Kanako HagioHiroko Yamashita
Jul 29, 2021·Acta Oncologica·Sannia SjöstedtKasper Aanaes
Aug 26, 2021·Scientific Reports·Thawaree NukpookChamsai Pientong