Genetic mutations associated with lung cancer metastasis to the brain

Mutagenesis
Hashim M AljohaniEl Mustapha Bahassi

Abstract

Approximately 90% of all cancer deaths arise from the metastatic spread of primary tumours. Of all the processes involved in carcinogenesis, local invasion and the formation of metastases are clinically the most relevant, but they are the least well understood at the molecular level. As a barrier to metastasis, cells normally undergo an apoptotic process known as 'anoikis', in circulation. The recent technological advances in the isolation and characterisation of rare circulating tumour cells (CTCs) will allow a better understanding of anoikis resistance. Detailed molecular and functional analyses of anoikis-resistant cells may provide insight into the biology of cancer metastasis and help identify novel targets for prevention of cancer dissemination. To uncover the molecular changes that govern the transition from a primary lung tumour to a secondary metastasis and specifically the mechanisms by which CTCs survive in circulation, we carried out whole genome sequencing (WGS) of normal lung, primary tumours and the corresponding brain metastases from five patients with progressive metastatic non-small-cell lung carcinoma. We also isolated CTCs from patients with metastatic cancer and subjected them to whole genome amplification ...Continue Reading

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Citations

Jan 5, 2020·Journal of Translational Medicine·Bernardo Cacho-DíazLuis Alonso Herrera-Montalvo
Jun 6, 2018·Frontiers in Oncology·Rute M S M PedrosaJohan M Kros
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Aug 17, 2021·Dose-response : a Publication of International Hormesis Society·Shuai XuHong Zhang
Aug 28, 2021·Cells·Miriam Sánchez-OrtegaAntonio Garrido

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