Genetic Mutations in Young Nonsmoking Patients With Oral Cavity Cancer: A Systematic Review

OTO Open : the Official Open Access Journal of the American Academy of Otolaryngology--Head and Neck Surgery Foundation
Rohini R BahethiBrittany Barber

Abstract

This investigation aims to review the known genetic mutations associated with oral cavity squamous cell carcinoma (OCSCC) in young adults with limited environmental risk factors (YLERs). A comprehensive search strategy was designed to identify studies in MEDLINE (Ovid), Embase (Ovid), and Scopus from database inception to May 2017 that included adults ≤50 years of age with OCSCC and minimal tobacco use history (≤10 pack-years) who had their tumors genetically sequenced or mutational profiles analyzed. Identified articles were screened by 2 reviewers. Quality of evidence was graded by the MINORS criteria for case-control studies; other studies were graded by assigning a level of evidence for gene mutation literature. Thirteen studies met our inclusion criteria, and 130 patients met our criteria for age and tobacco history. TP53 was the most commonly evaluated gene (10 of 13 studies) and the most frequently observed mutation. One study reported that nonsmokers had significantly fewer TP53 mutations, while 9 studies found no difference in the prevalence of TP53 mutations. No other mutations were found specific to this cohort. TP53 mutations may occur at a similar rate in YLERs with OCSCC as compared with older patients or those wi...Continue Reading

References

Jul 1, 1992·European Journal of Cancer. Part B, Oral Oncology·J K Field
Dec 1, 1996·Archives of Otolaryngology--head & Neck Surgery·S AtulaS Syrjänen
May 1, 1997·Archives of Otolaryngology--head & Neck Surgery·D M SorensenW A Franklin
Oct 16, 1999·The Laryngoscope·W M KochD Sidransky
Jan 6, 2000·Oral Oncology·Y T JinA K el-Naggar
Mar 18, 2005·Cancer·Caroline H ShiboskiRichard C K Jordan
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Apr 11, 2009·Head & Neck·Vladimir VinarskyHarold Frucht
Jul 23, 2009·Annals of Internal Medicine·David MoherUNKNOWN PRISMA Group
Mar 23, 2010·Journal of the American Academy of Dermatology·Barbara C BöckleNorbert T Sepp
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sagar C PatelBhishamjit S Chera
Apr 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marlon Lindenbergh-van der PlasBoudewijn J M Braakhuis
Mar 28, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Megan L DurrSteven J Wang
Jan 17, 2014·The Laryngoscope·Chase M HeatonSteven J Wang
Jan 18, 2014·International Journal of Cancer. Journal International Du Cancer·Annette M LimBenjamin Solomon
May 31, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Curtis R PickeringJeffrey N Myers
Sep 23, 2014·BMC Cancer·Daniel S W TanN Gopalakrishna Iyer
Jan 24, 2015·International Journal of Epidemiology·Tatiana Natasha ToporcovVictor Wünsch Filho
May 16, 2015·Cancer Epidemiology·Darien J WeatherspoonIsabel Garcia
Aug 5, 2017·BMC Medical Genetics·Gerardo Garcia-RivasVictor Trevino
Nov 21, 2017·Journal of Oral Microbiology·Manosha PereraNewell W Johnson
Mar 28, 2018·BMC Cancer·Priscila Marinho de AbreuSandra Lúcia Ventorin von Zeidler
Apr 10, 2018·The British Journal of Oral & Maxillofacial Surgery·R C-P MartinezM Robinson
Aug 14, 2018·Oral Oncology·Matt LechnerTim R Fenton
Dec 12, 2018·Oral Oncology·Benjamin R CampbellKrystle A Lang Kuhs
Jun 12, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mohd Hafiz ArzmiMichael McCullough

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Methods Mentioned

BETA
PCR

Software Mentioned

Scopus
Ovid
MEDLINE
Embase

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