Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891

Chembiochem : a European Journal of Chemical Biology
Felipe LombóCarmen Méndez

Abstract

The oviedomycin biosynthetic gene cluster from Streptomyces antibioticus ATCC 11891 has been sequenced and characterized. It contains all the necessary genes for oviedomycin biosynthesis, together with several genes for the generation of malonyl-CoA extender units. Production of this unusual angucyclinone in its natural host occurs only in solid cultures in parallel with aerial mycelium and spore formation. A mutant that did not produce oviedomycin was generated by disruption of the beta-ketoacyl synthase gene ovmK. No other physiological process in the mutant appears to be affected; this rules out a direct relationship between oviedomycin production and cell differentiation in S. antibioticus.

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Citations

Sep 30, 2006·Archives of Microbiology·Krzysztof PawlikEriko Takano
Mar 29, 2008·Archives of Microbiology·Iryna OstashVictor Fedorenko
Oct 20, 2012·Applied Microbiology and Biotechnology·Peter KutasJan Kormanec
Nov 23, 2013·Applied Microbiology and Biotechnology·Jan KormanecLubomira Feckova
Apr 2, 2010·Natural Product Reports·Hui ZhouYi Tang
Dec 21, 2013·Microbial Cell Factories·Héctor RodríguezRamón I Santamaría
Nov 7, 2008·Chembiochem : a European Journal of Chemical Biology·Felipe LombóCarmen Méndez
Sep 1, 2006·Molecular Microbiology·Neil BateEric Cundliffe
Jun 21, 2015·Biochimica Et Biophysica Acta·Alba Romero-RodríguezSergio Sánchez
Dec 22, 2011·Natural Product Reports·Madan K KharelJürgen Rohr
Sep 6, 2013·Microbiology and Molecular Biology Reviews : MMBR·Leslie Cuthbertson, Justin R Nodwell
Feb 3, 2007·Natural Product Reports·Christian HertweckAndreas Bechthold
Apr 18, 2012·Beilstein Journal of Organic Chemistry·Orwah SalehLutz Heide
Feb 24, 2011·Microbial Biotechnology·Carlos OlanoJosé A Salas

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