PMID: 9440511Jan 24, 1998Paper

Genetic organization of the mecA region in methicillin-susceptible and methicillin-resistant strains of Staphylococcus sciuri

Journal of Bacteriology
S WuAlexander Tomasz

Abstract

A homolog of the Staphylococcus aureus methicillin resistance gene mecA was recently shown to be ubiquitous in independent isolates of the animal species Staphylococcus sciuri. The mecA gene homolog and regions flanking it were cloned and sequenced from four strains of S. sciuri: strain K1 (ATCC 29062), a representative of S. sciuri subsp. sciuri; two strains (K3 and K8) representing S. sciuri subsp. rodentius; and strain K11, a representative of S. sciuri subsp. carnaticum. Strains K1 and K11 were susceptible to methicillin, while strains K3 and K8 showed heterogeneous resistance. The mecA genes of strains K1 and K11 and one of the two copies of mecA (mecA1) present in strain K3 had virtually identical DNA sequences in the mecA gene and were similar in genetic organization in the flanking regions. In contrast, the single copy of mecA in strain K8 and the second copy of mecA (mecA2) in strain K3 had mecA DNA sequences identical to that of S. aureus mecA, and the mecA region in these two strains was also similar to that of the same region in the S. aureus strain used for comparison. Interestingly, an open reading frame defining an N-terminal truncated polypeptide, NTORF101, with a high degree of homology to a DNA segment in the ...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M Nei, W H Li
Sep 25, 1990·Nucleic Acids Research·L Barberis-MainoB Berger-Bächi
Jan 1, 1986·Antimicrobial Agents and Chemotherapy·B J Hartman, A Tomasz
Oct 1, 1985·The Journal of Antimicrobial Chemotherapy·R Fontana
Oct 1, 1994·Trends in Microbiology·G L Archer, D M Niemeyer
Mar 1, 1994·Antimicrobial Agents and Chemotherapy·G L ArcherM J Pucci
Jan 1, 1996·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·I CoutoA Tomasz

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Citations

Jan 26, 2000·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·K SieradzkiA Tomasz
Aug 21, 2002·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Isabel BogadoAlejandro Viale
Nov 9, 2004·Folia Microbiologica·J StepánJ Doskar
Aug 4, 2010·Antimicrobial Agents and Chemotherapy·Sae TsubakishitaKeiichi Hiramatsu
Oct 4, 2014·Clinical Microbiology Reviews·Karsten BeckerGeorg Peters
Jan 6, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·B ShopsinB N Kreiswirth
Jun 28, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Henry C BaggettJay C Butler
Jun 27, 2000·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·H de LencastreH Westh
May 18, 2001·FEMS Microbiology Letters·S StepanovićM Svabić-Vlahović
Jul 17, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·T Hauschild, S Schwarz
Feb 19, 2014·The Journal of Antimicrobial Chemotherapy·Joana RoloMaria Miragaia
Apr 20, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M D NahviD T Dubin
Oct 6, 2005·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mohammed Tanvir RahmanMasaho Ishino
Feb 6, 2008·FEMS Microbiology Reviews·André ZapunThierry Vernet
Sep 15, 2010·Antimicrobial Agents and Chemotherapy·J A SeverinUNKNOWN AMRIN Study Group
Jan 21, 2010·Antimicrobial Agents and Chemotherapy·Sae TsubakishitaKeiichi Hiramatsu
Jul 6, 2000·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·B D Cookson
Mar 17, 2010·Journal of Veterinary Emergency and Critical Care·Leah A Cohn, John R Middleton
Sep 14, 2018·Clinical Microbiology Reviews·Sahreena Lakhundi, Kunyan Zhang
Sep 30, 2019·International Journal of Medical Microbiology : IJMM·Veronika VrbovskáRoman Pantůček
Feb 4, 2006·Journal of Clinical Microbiology·Seidu MalikMary D Barton
Mar 4, 2000·Journal of Clinical Microbiology·I CoutoH de Lencastre

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