genetic overexpression of NR2B subunit enhances social recognition memory for different strains and species.

PloS One
Stephanie Jacobs, J Z Tsien

Abstract

The ability to learn and remember conspecifics is essential for the establishment and maintenance of social groups. Many animals, including humans, primates and rodents, depend on stable social relationships for survival. Social learning and social recognition have become emerging areas of interest for neuroscientists but are still not well understood. It has been established that several hormones play a role in the modulation of social recognition including estrogen, oxytocin and arginine vasopression. Relatively few studies have investigated how social recognition might be improved or enhanced. In this study, we investigate the role of the NMDA receptor in social recognition memory, specifically the consequences of altering the ratio of the NR2B:NR2A subunits in the forebrain regions in social behavior. We produced transgenic mice in which the NR2B subunit of the NMDA receptor was overexpressed postnatally in the excitatory neurons of the forebrain areas including the cortex, amygdala and hippocampus. We investigated the ability of both our transgenic animals and their wild-type littermate to learn and remember juvenile conspecifics using both 1-hr and 24-hr memory tests. Our experiments show that the wild-type animals and NR...Continue Reading

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Citations

Oct 10, 2013·The International Journal of Neuroscience·Qing WangXufeng Huang
Oct 30, 2014·Expert Opinion on Therapeutic Patents·Katie L StrongDennis C Liotta
Aug 26, 2014·Expert Opinion on Therapeutic Targets·Deheng WangJoe Z Tsien
Aug 7, 2012·Journal of Neurochemistry·Jon-Eric Vanleeuwen, Peter Penzes
Sep 22, 2012·Current Opinion in Neurobiology·Bernard Crespi
May 21, 2013·Nature Reviews. Neuroscience·Pierre PaolettiQiang Zhou
Aug 17, 2019·Frontiers in Molecular Neuroscience·Gloria Lee, Yi Zhou
Nov 14, 2019·International Journal of Molecular Sciences·Iulia Zoicas, Johannes Kornhuber
Nov 14, 2019·Genes, Brain, and Behavior·Sarah L FerriEdward S Brodkin
May 16, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Saidan DingQichuan Zhuge
Jul 17, 2015·Learning & Memory·Stephanie JacobsJoe Z Tsien

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Methods Mentioned

BETA
transgenic
PCR
biopsy

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