Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders.

Translational Psychiatry
Wikus BarkhuizenAngelica Ronald

Abstract

This study explores the degree to which genetic influences on psychotic experiences are stable across adolescence and adulthood, and their overlap with psychiatric disorders. Genome-wide association results were obtained for adolescent psychotic experiences and negative symptom traits (N = 6297-10,098), schizotypy (N = 3967-4057) and positive psychotic experiences in adulthood (N = 116,787-117,794), schizophrenia (N = 150,064), bipolar disorder (N = 41,653), and depression (N = 173,005). Linkage disequilibrium score regression was used to estimate genetic correlations. Implicated genes from functional and gene-based analyses were compared. Mendelian randomization was performed on trait pairs with significant genetic correlations. Results indicated that subclinical auditory and visual hallucinations and delusions of persecution during adulthood were significantly genetically correlated with schizophrenia (rg = 0.27-0.67) and major depression (rg = 0.41-96) after correction for multiple testing. Auditory and visual subclinical hallucinations were highly genetically correlated (rg = 0.95). Cross-age genetic correlations for psychotic experiences were not significant. Gene mapping and association analyses revealed 14 possible genes...Continue Reading

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Citations

Sep 29, 2020·Frontiers in Psychology·Saskia de Leede-SmithEmma Barkus
Jun 2, 2021·Journal of the American Academy of Audiology·Frank E MusiekAlyssa J Davidson
May 2, 2021·Journal of the American Academy of Child and Adolescent Psychiatry·Wonuola A AkingbuwaChristel M Middeldorp
Jul 23, 2021·Scientific Reports·Wikus BarkhuizenAngelica Ronald

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