Genetic Parameter Estimates for Metabolizing Two Common Pharmaceuticals in Swine

Frontiers in Genetics
Jeremy T HowardChristian Maltecca

Abstract

In livestock, the regulation of drugs used to treat livestock has received increased attention and it is currently unknown how much of the phenotypic variation in drug metabolism is due to the genetics of an animal. Therefore, the objective of the study was to determine the amount of phenotypic variation in fenbendazole and flunixin meglumine drug metabolism due to genetics. The population consisted of crossbred female and castrated male nursery pigs (n= 198) that were sired by boars represented by four breeds. The animals were spread across nine batches. Drugs were administered intravenously and blood collected a minimum of 10 times over a 48 h period. Genetic parameters for the parent drug and metabolite concentration within each drug were estimated based on pharmacokinetics (PK) parameters or concentrations across time utilizing a random regression model. The PK parameters were estimated using a non-compartmental analysis. The PK model included fixed effects of sex and breed of sire along with random sire and batch effects. The random regression model utilized Legendre polynomials and included a fixed population concentration curve, sex, and breed of sire effects along with a random sire deviation from the population curve a...Continue Reading

References

May 10, 2000·American Journal of Veterinary Research·M B Petersen, C Friis
Sep 9, 2006·Journal of Veterinary Pharmacology and Therapeutics·J L BuurJ E Riviere
Feb 3, 2012·Public Health Reports·Timothy F LandersElaine L Larson
Aug 15, 2013·BMC Veterinary Research·Monique D Pairis-GarciaJohann F Coetzee
Sep 8, 2015·Clinical Pharmacology and Therapeutics·J MatthaeiR Kerb
Jun 16, 2016·Scientific Reports·Zhoumeng LinJim E Riviere

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