Genetic parameters for antibody response of chickens to sheep red blood cells based on a selection experiment

Poultry Science
H BovenhuisH K Parmentier

Abstract

In the present study, a selection experiment for antibody (Ab) titer against SRBC in chickens was analyzed. Two lines were divergently selected for increased and decreased Ab titer. Further, a randombred control line, originating from the same base population, was included in the experiment. The heritability for immune response against SRBC was estimated after 18 generations of selection. In total, Ab titers obtained from 16,459 chickens were included in the analysis. Data was analyzed using an animal model. Posterior distributions for variance components and heritability were obtained using Markov Chain Monte Carlo methods. Response to selection was evaluated by constructing the posterior distribution for the genetic trend. In addition, a bivariate animal model was used in which male and female antibody titers were treated as different traits to estimate correlations between male and female immune response against SRBC. The heritability of Ab titer response, when using information from all three lines, was 0.18. The 90% highest posterior density region for the estimated heritability ranged from 0.16 to 0.19. In Generation 18, the genetic difference between the high and the low line was 5.1 phenotypic standard deviations. Analy...Continue Reading

Citations

Dec 23, 2003·Animal Genetics·M SiwekJ J van der Poel
Aug 11, 2011·PloS One·Laurence FloriClaire Rogel-Gaillard
Nov 20, 2018·Animal : an International Journal of Animal Bioscience·V RaeesiR V Torshizi

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