Genetic polymorphism and expression of HSF1 gene is significantly associated with breast cancer in Saudi females

PloS One
Sahar AlmotwaaArjumand Warsy

Abstract

The transcription factor, heat shock factor 1 (HSF1), influences the expression of heat shock proteins as well as other activities like the induction of tumor suppressor genes, signal transduction pathway, and glucose metabolism. We hypothesized that single nucleotide polymorphisms (SNPs) in HSF1 gene might affect its expression or function which might have an influence on the development of breast cancer. The study group included 242 individuals (146 breast cancer patients and 96 healthy controls). From the cancer patients, genomic DNA was extracted from 96 blood samples and 50 Formalin-Fixed Paraffin Embedded (FFPE) tissues, while from the controls DNA were extracted from blood only. Genotype was carried out for four SNPs in the HSF1 gene (rs78202224, rs35253356, rs4977219 and rs34404564) using Taqman genotyping assay method. The HSF1 expression was investigated using immunohistochemistry on FFPE tissues (cancer tissue and adjacent normal tissue). The SNP rs78202224 (G>T) was significantly associated with increased risk of breast cancer. The combined TT + GT genotype (OR: 6.91; p: 0.035) and the T allele showed high risk (OR: 5.81; p:0.0085) for breast cancer development. The SNP rs34404564 (A>G) had a protective effect again...Continue Reading

References

May 30, 1997·The Journal of Biological Chemistry·P A MercierJ T Westwood
Sep 26, 2003·Nature·Len Neckers, Yong-Sok Lee
May 29, 2007·Cellular and Molecular Life Sciences : CMLS·M Breuleux
Jun 13, 2009·Future Oncology·Shinji TsutsumiLen Neckers
Feb 19, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vikas DudejaAshok K Saluja
Aug 4, 2011·The Journal of Antibiotics·Hiroshi YamakiNobuo Tanaka
Nov 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sandro SantagataTan A Ince
Nov 23, 2011·Journal of Cellular Biochemistry·Stuart K Calderwood, Jianlin Gong
Sep 15, 2012·Biochemical and Biophysical Research Communications·Ruma SarkarMadhumita Roy
Oct 13, 2012·Pathology, Research and Practice·Soya S SamJoel A Lefferts
Apr 26, 2013·Oncotarget·Yaoyu ChenWenlai Zhou
Jan 15, 2014·Journal of Cell Science·Anniina Vihervaara, Lea Sistonen
Jan 29, 2014·Current Cancer Drug Targets·Natalia VydraWieslawa Widlak
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Mar 1, 2015·Cancer Research·Trisha HomeRekha Rao
Jun 26, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sufang JiangYuhua Zhao
Aug 1, 2015·Breast Cancer Research and Treatment·Bin WangTan A Ince
Sep 12, 2015·Oncotarget·Ga-Young KangYun-Sil Lee
Nov 26, 2015·Trends in Cell Biology·Chengkai Dai, Stephen Byers Sampson

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

SPSS

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