Genetic polymorphism in selenoprotein P modifies the response to selenium-rich foods on blood levels of selenium and selenoprotein P in a randomized dietary intervention study in Danes

Genes & Nutrition
Tine Iskov KoppGitte Ravn-Haren

Abstract

Selenium is an essential trace element and is suggested to play a role in the etiology of a number of chronic diseases. Genetic variation in genes encoding selenoproteins, such as selenoprotein P and the glutathione peroxidases, may affect selenium status and, thus, individual susceptibility to some chronic diseases. In the present study, we aimed to (1) investigate the effect of mussel and fish intake on glutathione peroxidase enzyme activity and (2) examine whether single nucleotide polymorphisms in the GPX1, GPX4, and SELENOP genes modify the effect of mussel and fish intake for 26 weeks on whole blood selenium, plasma selenoprotein P concentrations, and erythrocyte GPX enzyme activity in a randomized intervention trial in Denmark. CC homozygotes of the SELENOP/rs3877899 polymorphism who consumed 1000 g fish and mussels per week for 26 consecutive weeks had higher levels of both selenoprotein P (difference between means - 4.68 ng/mL (95% CI - 8.49, - 0.871)) and whole blood selenium (difference between means - 5.76 (95% CI - 12.5, 1.01)) compared to fish and mussel consuming T-allele carriers although the effect in whole blood selenium concentration was not statistically significant. Our study indicates that genetically dete...Continue Reading

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Citations

Mar 20, 2019·Shock·Petra BüttnerHolger Thiele
Oct 4, 2020·Nutrients·Francisco Javier Turrubiates-HernándezJosé Francisco Muñoz-Valle
Jul 2, 2020·International Journal of Molecular Sciences·Anna BaranIwona Flisiak
Feb 12, 2021·Nutrition Reviews·Janaina L S DonadioMarcelo M Rogero

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Methods Mentioned

BETA
blood drawing
genotyping

Software Mentioned

SAS

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