Genetic polymorphism of angiotensin-converting enzyme and hypertrophic cardiomyopathy risk: A systematic review and meta-analysis

Medicine
Ye YuanNa Lu

Abstract

Genetic factors in the pathogenesis of cardiomyopathies have received a lot of attention during the past 2 decades. Some studies have reported that angiotensin-converting enzyme (ACE) gene has been associated with hypertrophic cardiomyopathy (HCM). However, there have been inconsonant results among different studies. To clarify the influence of ACE on HCM, a systemic review and meta-analysis of case-control studies were performed. The following databases were searched to indentify related studies: PubMed database, the Embase database, the Cochrane Central Register of Controlled Trials database, China National Knowledge Information database, and Chinese Scientific and Technological Journal database. Search terms included "hypertrophic cardiomyopathy," "angiotensin converting enzyme" or "ACE," and "polymorphism or mutation." Fifteen separate studies were suitable for the inclusion criterion. The selected studies contained 2972 participants, including 1047 in HCM group and 1925 controls. Pooled odds ratios (ORs) were calculated to assess the association between ACE insertion/deletion (I/D) polymorphism and HCM. Our case-control data indicated that D allele carrier is a risk allele in all genetic models: allele contrast (D vs I: OR...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jun 1, 1993·Circulation·K K GriendlingR W Alexander
Aug 1, 1996·The American Journal of Cardiology·A PfeuferF C Luft
Jun 30, 1996·Statistics in Medicine·R DerSimonian
Mar 13, 1997·The New England Journal of Medicine·P SpiritoB J Maron
Jan 1, 1997·Annual Review of Physiology·J Sadoshima, S Izumo
Apr 4, 1998·Journal of the American Animal Hospital Association·J E RushF W Smith
Jul 25, 2000·Circulation·B H Lorell, B A Carabello
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Nov 17, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Gysèle S BleuminkBruno H Ch Stricker
Jan 1, 2008·Molecular and Cellular Biochemistry·Taranjit Singh RaiMadhu Khullar
Jan 30, 2008·Nature Clinical Practice. Cardiovascular Medicine·Andre KerenWilliam J McKenna
Dec 17, 2008·The Journal of Molecular Diagnostics : JMD·Martin PenickaUNKNOWN Candesartan use in Hypertrophic And Non-obstructive Cardiomyopathy Estate (CHANCE) Study Investigators
May 1, 1999·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·C N AmbergerC W Lombard
Jul 11, 2009·Journal of the American College of Cardiology·J Martijn BosMichael J Ackerman
May 19, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Cansin Tulunay KayaCetin Erol
Mar 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nozomi KatoHiromi Rakugi
Apr 22, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Esteban Orenes-PiñeroFrancisco Marín
Nov 5, 2011·World Journal of Cardiology·Kazuaki NishioYouichi Kobayashi

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Citations

Jun 27, 2019·Medicina·Nicoleta Monica Popa-FoteaMaria Dorobantu
Apr 4, 2021·International Journal of Environmental Research and Public Health·Adrián Montes-de-Oca-GarcíaJesús G Ponce-González

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