Genetic polymorphism of CYP2E1 and digestive tract alcohol damage among Polish individuals

Alcoholism, Clinical and Experimental Research
Halina Cichoz-LachKrzysztof Celiński

Abstract

Genetic polymorphism of enzymes involved in alcohol metabolism plays a relevant role in etiopathogenesis of alcohol disease. The aim of the present study was to find in the Polish population the CYP2E1 genotypes that are likely to be responsible for higher susceptibility to alcohol disease of the liver and chronic alcohol pancreatitis. The CYP2E1 genotype and c1 and c2 alleles frequency were examined in 198 patients. Genotyping of the CYP2E1 was performed using polymerase chain reaction-restriction fragment length polymorphism methods on white cell DNA. In the examined population encompassing 198 subjects, the c2 allele was present only in 1.5% of patients. It was found only in patients abusing alcohol. In the group of patients with alcoholic cirrhosis, it was present in 3.5% of cases, whereas in patients with chronic alcoholic pancreatitis, in 2.3%. The genotype c1/c2 was present in 3% of subjects. The genotype c2/c2 was not found in any patient. Heterozygotes c1/c2 were present only in patients consuming excessive amounts of ethanol; in 7% of patients with alcoholic cirrhosis and in 4.5% of those with chronic alcoholic pancreatitis. The c2 allele occurred only in men. None of the examined women had the genotype c1/c2. Our stu...Continue Reading

References

Dec 11, 1990·Nucleic Acids Research·J WatanabeK Kawajiri
Jan 1, 1990·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·T EhrigT K Li
Feb 1, 1990·Drug and Alcohol Dependence·W B PickworthC Muntaner
Dec 10, 1987·Nucleic Acids Research·O W McBrideF J Gonzalez
Dec 22, 1988·The New England Journal of Medicine·C S Lieber
Jun 1, 1988·Biochemical Society Transactions·C S Lieber
Jan 1, 1981·Annual Review of Biochemistry·N E Tolbert
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·K IwahashiY Ichikawa
Jan 28, 1995·Lancet·S Sherlock
Apr 1, 1994·Gastroenterology·C S Lieber
Dec 1, 1996·Alcoholism, Clinical and Experimental Research·M MatsumotoH Ishii
Jun 15, 1997·Annals of Internal Medicine·E CeniA Casini
Jun 1, 1997·Alcoholism, Clinical and Experimental Research·F TanakaM Omata
Dec 16, 1998·JAMA : the Journal of the American Medical Association·J A Ewing
May 11, 1999·Alcoholism, Clinical and Experimental Research·K MaruyamaM Matsuno
Apr 25, 2003·Experimental and Molecular Pathology·Tamiko KonishiYu-Jui Yvonne Wan
Nov 8, 2003·World Journal of Gastroenterology : WJG·Yun-Feng PiaoYang Shi
Dec 24, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Mariette VerlaanJoost P H Drenth

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Citations

Apr 22, 2008·Yi chuan = Hereditas·Gen-Feng HeQiang Jing
Nov 24, 2007·Alcoholism, Clinical and Experimental Research·Min YangYu-Jui Yvonne Wan

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