Genetic polymorphism of CYP2U1, a cytochrome P450 involved in fatty acids hydroxylation

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Aurore DevosChristelle Cauffiez

Abstract

The human cytochrome P450 2U1 (CYP2U1) has been described as a novel extrahepatic P450. CYP2U1 is a highly conserved gene mainly expressed in brain and thymus, but also at lower levels in kidney, lung or heart. This selective tissue distribution suggests important endogenous functions, in particular in the conversion of arachidonic acid into two bioactive compounds, the 19- and 20-HETE. To investigate the extent of CYP2U1 genetic polymorphism in 70 French individuals, a screening for sequence variations in the 5'-flanking and protein encoding regions was performed using PCR-SSCP and sequencing strategies. Four polymorphisms were identified and correspond to -204C>A and -241T>C in the 5'-flanking region, -37G>A in the 5'-untranslated region, and IVS2-17T>C in the intron 2. The most frequent mutations, -241T>C (59.7%) and IVS2-17T>C (66.0%), did not seem to alter CYP2U1 lung expression. These results suggest that CYP2U1 exhibits few genetic variations and support a probable role in endogenous processes.

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Citations

Jun 1, 2013·In Vitro Cellular & Developmental Biology. Animal·Yazun Bashir JarrarSu-Jun Lee
Oct 12, 2010·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Christian Lacks Lino CardenasDany Chevalier
Aug 13, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yazun B JarrarSu-Jun Lee
Mar 19, 2014·Experimental Cell Research·Anne NoreauGuy A Rouleau
Jul 28, 2016·Biochimica Et Biophysica Acta. General Subjects·Laura DhersJean-Luc Boucher
Aug 11, 2016·Scientific Reports·Lin HanChanggui Li
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Jan 14, 2017·Cellular and Molecular Life Sciences : CMLS·L DhersD Mansuy

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