Genetic polymorphism of HPA1-17 alloantigen system in the Achang and Jingpo populations population in Yunnan.

Annals of Palliative Medicine
Weiqun DongSui Wu

Abstract

Human platelet alloantigen (HPA) is part of the platelet membrane structure, named HPA1- 17 system. This study aimed to investigate platelet alloimmunity in the Achang and Jingpo population, ethnic minority specific, to establish a typed platelet donor data bank in Yunnan's ethnic minority areas. In this study, samples from 139 unrelated healthy cases from the Achang population, 148 cases of the Jingpo population, and 150 healthy cases from Yunnan's Han population were collected as a control. PCR-sequence specific primers (PCR-SSP) methods were respectively adopted to genotype HPA-1-17. The frequency of genes and genotypes was calculated separately, and the frequency distribution of alleles in the Achang population was compared with that of the Han population. Monomorphic HPA-7-14 and HPA-16 and 17 were found in the samples from the Han population, while HPA-b was not found in any of these samples. In HPA-1, 2, 4, 5, and 6, aa homozygosity was predominant. Monomorphic HPA-7, HPA-9-14 and HPA-16 were found in the samples from the Achang population, while HPA-b was not found. In HPA-1, 2, 4, 5, 6, 8, and 17, aa homozygosity was predominant. The genotype results of the HPA-4, 7, HPA9-12, HPA14, 16-17 antigen systems in the Jingpo ...Continue Reading

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