Genetic Polymorphism of MMP2 Gene and Susceptibility to Prostate Cancer

Archives of Medical Research
Zahra AdabiMandana Hasanzad

Abstract

The polymorphic genetic variants of matrix metalloproteinase (MMPs) can play critical roles in development and progression of cancer. The purpose of this study was to investigate if any association exists between MMP2 -1306/T and risk of prostate cancer (PCa). This case-control study comprised a total number of 241 subjects, including 102 patients with PCa and 139 controls with benign prostatic hyperplasia (BPH). MMP2 genotypes were detected by RFLP. There is no significant difference between different genotypes of MMP2 polymorphism and risk of developing PCa (p = 0.08). Although these genotypes increased the risk of developing PCa 79% (CT vs. CC) and 54% (TT vs. CC), none had a significant effect (p = 0.09 and p = 1 respectively). There were no significant differences in genotype frequencies between patients with low and high degrees of PCa (p = 0.4). Therefore, this polymorphism cannot be considered as a protective factor for PCa metastasis. It seems that MMP2 polymorphism has no protective effect on the grading of the tumor (p = 0.8). Our results indicated that MMP2 polymorphism had no role in the vascular invasion of PCa. We found no association between MMP2 polymorphism and cancer risk, overall or by grade, stage or age of...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jan 25, 2003·Journal of Biochemistry and Molecular Biology·Sang-Oh YoonAn-Sik Chung
Jan 30, 2004·Human Molecular Genetics·Daniel J Schaid
Apr 17, 2004·Virchows Archiv : an International Journal of Pathology·Christian G SauerRainer Grobholz
Apr 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Eric J JacobsCarmen Rodriguez
Jan 2, 2009·Urologic Oncology·Sabrina Thalita dos ReisKatia Ramos Moreira Leite
Mar 24, 2009·The Journal of Urology·Sabrina Thalita Dos ReisKatia Ramos Moreira Leite
Apr 1, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yihong HuaYuejin Yang
Jun 10, 2009·International Journal of Cancer. Journal International Du Cancer·Peter McColgan, Pankaj Sharma
Mar 1, 2012·Archives of Medical Research·Priyanka SrivastavaRama Devi Mittal
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Apr 5, 2014·BioMed Research International·Thomas Van den BroeckFrank Claessens

❮ Previous
Next ❯

Citations

Jan 29, 2016·Biosensors & Bioelectronics·Yung-Chieh ChanMichael Hsiao
Apr 4, 2021·International Journal of Molecular Sciences·Marley J Binder, Alister C Ward

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.