Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals

Cancer Immunology, Immunotherapy : CII
Elissaveta NaumovaMiglena Toneva

Abstract

Antitumor cytotoxicity of NK cells and T cells expressing NK-associated receptors is regulated by interaction between their cell surface killer immunoglobulin-like receptors (KIRs) and CD94/NKG2 heterodimers with MHC class I ligands on target cells. To test the hypothesis that KIR and/or HLA polymorphisms, and KIR/HLA combinations could contribute to the tumorigenesis, association studies were performed in 50 patients with malignant melanoma (MM) in different stages of disease and 54 controls. Our data showed that the frequency of inhibitory and activating KIR genes and KIR genotypes did not differ significantly between healthy individuals and melanoma patients. HLA haplotype distribution showed statistically significant increased frequencies of A*01-B*35-Cw*04 (0.069 vs 0.000; pc < 0.05; OR = 19.9), A*01-B*08-DRB1*03 (0.079 vs 0.019; pc < 0.05; OR = 4.5), and A*24-B*40-DRB1*11 (0.026 vs 0.000; pc < 0.05; OR = 7.1) in melanoma patients compared with healthy controls. Individuals homozygous for group 2 HLA-C ligands were less frequent in the patient group compared with the control cohort (12% vs 31.5%; p < 0.017). In addition, we observed an increased frequency (88.0% vs 68.5%; p = 0.017; OR = 2.80) of KIR2DL2/2DL3 in combinatio...Continue Reading

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M ColonnaO Viale
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Nov 15, 1994·International Journal of Cancer. Journal International Du Cancer·J E LeeC D Platsoucas
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M ColonnaJ L Strominger
Oct 1, 1993·Immunology Today·F GarridoP L Stern
Jan 1, 1995·Advances in Cancer Research·F GarridoF Ruiz-Cabello
May 1, 1996·Tissue Antigens·F Garrido
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·A PorgadorJ L Strominger
Jan 16, 1998·Immunity·M UhrbergP Parham
Nov 10, 1998·Journal of Immunotherapy·M L LombardiC Manzo
Dec 29, 1998·Immunology Today·F Ruiz-Cabello, F Garrido
Feb 24, 2000·The Journal of Experimental Medicine·M J SmythD I Godfrey
Mar 23, 2001·Nature Immunology·A M MoodycliffeS E Ullrich
Jul 23, 2002·Nature Genetics·Maureen P MartinMary Carrington
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Eva SingletaryFrederick L Greene
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen P MartinMary Carrington

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Citations

Sep 3, 2010·Cancer Immunology, Immunotherapy : CII·Bangwei CaoShutian Zhang
May 7, 2013·Journal of Dermatological Science·Łukasz MatusiakJacek C Szepietowski
Apr 6, 2005·The Journal of Experimental Medicine·Sumati Rajagopalan, Eric O Long
Mar 25, 2009·Genetic Testing and Molecular Biomarkers·Rami A R MahfouzRoy A Khalaf
Jul 11, 2006·Annual Review of Genomics and Human Genetics·Arman A BashirovaMary Carrington
Dec 25, 2012·Yi chuan = Hereditas·Min-Zhong TangYi Zeng
May 13, 2005·Cancer Immunology, Immunotherapy : CII·Javier G CasadoRaquel Tarazona
Mar 21, 2006·Cancer Immunology, Immunotherapy : CII·Elissaveta NaumovaSnejina Mihailova
Apr 12, 2011·Medical Oncology·Ozlem Goruroglu OzturkGurbuz Polat
Jul 19, 2008·Seminars in Immunology·Smita KulkarniMary Carrington
May 25, 2007·Clinical and Experimental Immunology·R J Boyton, D M Altmann
Nov 15, 2006·Immunological Reviews·Salim I Khakoo, Mary Carrington
Mar 22, 2016·Fish & Shellfish Immunology·Dustin J Wcisel, Jeffrey A Yoder
Nov 3, 2016·Leukemia·Meral BeksacParameswaran Hari
Jun 6, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Gordana KonjevićIvan Spuzić
May 27, 2017·Scientific Reports·Anaïs ChapelMarcus Altfeld
Jul 15, 2020·Reproductive Sciences·Maria Lucia Carnevale MarinJorge Kalil
Jan 14, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Snezhina Mihailova KandilarovaElissaveta Naumova
May 24, 2014·Molecular Biology Reports·Romina DastmalchiAliakbar Amirzargar
Aug 30, 2011·Journal of Leukocyte Biology·Olympe ChazaraAshley Moffett
Jan 23, 2021·Expert Review of Clinical Immunology·Azadehsadat RazaviNima Rezaei

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